250279-64-2

Upstream product

• 250279-58-4 3-azido-4-O-benzyl-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propane-1,3-diyl dithioacetal 
• 250279-77-7 Trifluoro-methanesulfonic acid (1S,2S,3S)-3-azido-2-benzyloxy-4-[1,3]dithian-2-yl-1-trifluoromethyl-butyl ester 
• 250279-57-3 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentose propan-1,3-diyl dithioacetal 
• 250279-61-9 3-azido-4-O-benzyl-2,3-dideoxy-6,6,6-trifluoro-L-lyxo-hexose propane-1,3-diyl dithioacetal 
• 250279-62-0 3-azido-4-O-benzyl-2,3,6-trideoxy-6,6,6-trifluoro-D-ribo-hexose propane-1,3-diyl dithioacetal 
• 250279-59-5 3-azido-4-O-benzyl-2,3-dideoxy-D-erythro-pentose propane-1,3-diyl dithioacetal 
• 114071-63-5 methyl 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-α-D-erythro-pentofuranoside 
• 108-24-7 acetic anhydride 

Downstream Products

• 250279-68-6 1-O-acetyl-3-amino-2,3,6-trideoxy-6,6,6-trifluoro-L-lyxo-hexopyranose 
• 250279-67-5 1-O-acetyl-3-amino-4-O-benzyl-2,3,6-trideoxy-6,6,6-trifluoro-L-lyxo-hexopyranose 

Relevant academic research and scientific papers

Synthesis and antitumor activity of 5'-demethyl-5'-trifluoromethyl-daunorubicin and -doxorubicin

The title compounds were prepared by coupling phenyl 4-O-acetyl-2,3,6-trideoxy-6,6,6-trifluoro-1-thio-3-trifluoroacetamido-α-L- and β-L-lyxo-hexopyranoside with daunomycinone. The key step of this synthesis is the C-trifluoromethylation of a 1-protected 2,3-dideoxy-3-azido-D-erythro-pentodialdose, prepared from 2-deoxy-D-erythro-pentose, to give a 6,6,6-trifluoro-L-lyxo-hexose derivative. The synthetic products showed higher cytotoxicity than doxorubicin against most of the human tumor cell lines tested in vitro, possibly by the effect of the CF3 group at C-5'. Copyright (C) 1999 Elsevier Science Ltd.