25028-33-5

Usage

Main properties

1. Derived from isonicotinic acid
2. Molecular formula: C9H7NO3
3. Yellow solid
4. Sparingly soluble in water
5. Used as a building block in the synthesis of pharmaceutical and agrochemical compounds
6. Known for its anti-inflammatory and antiseptic properties
7. Used in the production of drugs for treating respiratory infections and inflammatory diseases
8. Studied for its potential as a chelating agent
9. Used in the preparation of metal complexes for various applications in chemistry and materials science
10. Valuable for its diverse range of applications in medicine and chemical research

Specific content

1. Chemical compound derived from isonicotinic acid
2. Molecular formula: C9H7NO3
3. Yellow solid with sparing solubility in water
4. Used as a building block in pharmaceutical and agrochemical synthesis
5. Anti-inflammatory and antiseptic properties
6. Key ingredient in drugs for respiratory infections and inflammatory diseases
7. Studied for chelating capabilities
8. Used in preparation of metal complexes for chemistry and materials science applications
9. Valuable for diverse applications in medicine and chemical research

InChI:InChI=1/C8H7NO3/c1-5(10)7-4-6(8(11)12)2-3-9-7/h2-4H,1H3,(H,11,12)

Upstream product

• 138715-82-9 methyl 2-acetylpyridine-4-carboxylate 

Downstream Products

• 1013035-56-7 C₁₆H₁₅N₃O₂S₂ 

Relevant academic research and scientific papers

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Spiro derivative, preparation method thereof and application of spiro derivative in medicine

The invention relates to a spiro derivative, a preparation method thereof and application of the spiro derivative in medicine. Specifically, the invention relates to the spiro derivative shown in a general formula (I), the preparation method thereof, a pharmaceutical composition containing the spiro derivative and application of the spiro derivative as a therapeutic agent, especially application of the spiro derivative as an RAF inhibitor and application of the spiro derivative in preparation of drugs for treating or preventing various diseases (including cancers) related to over-expression RAF activity.

Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration

We screened the National Cancer Institute Diversity Set compound collection for small molecules that affect mammalian cell migration and identified NSC 295642 as an inhibitor of cell motility with nanomolar potency. We found by LC-MS and X-ray crystallogr