25033-14-1

Basic information

• Product Name: 4-Nitrothiobenzoic acid methyl ester
• Synonyms: 4-Nitrothiobenzoic acid methyl ester;p-Nitrothiobenzoic acid O-methyl ester
• CAS NO: 25033-14-1
• Molecular Formula: C₈H₇NO₃S
• Molecular Weight: 197.21
• Mol File: 25033-14-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Nitrothiobenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrothiobenzoic acid methyl ester(25033-14-1)
• EPA Substance Registry System: 4-Nitrothiobenzoic acid methyl ester(25033-14-1)

Safety Data

• Hazardous Substances Data: 25033-14-1(Hazardous Substances Data)

Upstream product

• 619-72-7 4-nitrobenzonitrile 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 39739-52-1 methyl imini ester hydrochloride of 4-nitrobenzoic acid 

Downstream Products

• 1035868-72-4 C₁₇H₁₂N₂O₄S 
• 1035868-83-7 C₁₈H₁₄N₂O₄S 
• 126336-35-4 1-(Dimethoxy-methylsulfanyl-methyl)-4-nitro-benzene 

Relevant articles and documents

P4S10/dimethicone tandem: Efficient reagent for thionation of various aromatic amides and esters

Organosulfur compounds are valuable because of their rich and varied chemistry especially in biological field. We report a new and efficient way for thionation of various aromatic amides and esters using P4S 10/ dimethicone tandem. The ease of handling and higher yield makes this protocol economical.

Thionation of esters and lactones with the reagent combination of phosphorus pentasulfide and hexamethyldisiloxane

The combination of P4S10 and hexamethyldisiloxane converts esters and lactones to thionoesters and thionolactones in yields comparable to or superior to those obtained with Lawesson's reagent. The method has the advantage that reagent-derived byproducts may be removed by a simple hydrolytic workup or by filtration through silica gel, rather than by chromatography, as required for Lawesson's reagent.

THIONO AND DITHIOCARBOXYLIC ESTERS WITH ADDITIONAL FUNCTIONAL GROUPS

Since powerful nucleophiles and reductants or electrophiles are required for the synthesis of thiono and dithio esters, severe difficulties arise if certain other functional groups are present in the precursor.Furthermore, strong interference may occur between a reactive substituent and the thio ester group once they are both present in a molecule. - It is, therefore, necessary - and possible - to choose thoroughly a selective method, if thiono or dithio esters with halogeno, nitro, or oxo substituents as well as bis-thiono and bis-dithio esters are to be prepared.