25033-19-6

Basic information

• Product Name: 1-cyclopropylnaphthalene
• Synonyms: 1-cyclopropylnaphthalene;1-cyclopropylnapthalene;1-Naphthylcyclopropane;Lesinurad Impurity 15
• CAS NO: 25033-19-6
• Molecular Formula: C₁₃H₁₂
• Molecular Weight: 168.23438
• EINECS: 1308068-626-2
• Product Categories: Lesinurad (RDEA-594);Naphthalene series;strong recommend
• Mol File: 25033-19-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 152-154 °C(Press: 18 Torr)
• Appearance: /
• Density: 1.110
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-cyclopropylnaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropylnaphthalene(25033-19-6)
• EPA Substance Registry System: 1-cyclopropylnaphthalene(25033-19-6)

Safety Data

• Hazardous Substances Data: 25033-19-6(Hazardous Substances Data)

Usage

Uses

1-Cyclopropylnaphthalene can be a starting material in the synthesis of 3-hydroxy-3-naphthyl-propyl nitrate. 1-Cyclopropylnaphthalene is a derivative of Naphthalene (N345600). Naphthalene is an abundant polycyclic aromatic hydrocarbon that is persistent, bioaccumulative, toxic and found in tobacco smoke and urban air.

Upstream product

• 91954-77-7 3-naphthalen-1-yl-4,5-dihydro-1H-pyrazole 
• 826-74-4 1-vinylnaphthalene 
• 74-95-3 1,1-dibromomethane 
• 90-11-9 1-Bromonaphthalene 
• 23719-80-4 cyclopropylmagnesium bromide 
• 5409-58-5 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride 
• 86-57-7 1-Nitronaphthalene 
• 411235-57-9 cyclopropylboronic acid 
• 98-86-2 acetophenone 
• 98-85-1 1-Phenylethanol 
• 100-42-5 styrene 
• 38365-57-0 1,1-Dichlor-2-α-naphthylcyclopropan 
• 3002-94-6 cyclopropyllithium 
• 90-13-1 1-Chloronaphthalene 

Downstream Products

• 878671-96-6 3-amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 
• 1533519-87-7 1-amino-4-cyclopropylnaphthalene oxalate 
• 1533519-90-2 C₁₅H₁₇N₅S*ClH 
• 1533519-86-6 N-(4-cyclopropylnaphthalen-1-yl)-2-formylhydrazine-1-thiocarboxamide 
• 1533519-84-4 4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol 
• 1533519-85-5 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-yl)thio)acetic acid methyl ester 
• 878672-00-5 (-)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 878672-00-5 (+)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 1158970-60-5 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid potassium salt 
• 1158970-52-5 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid ethyl ester 

Relevant articles and documents

Method for preparing 1-cyclopropylnaphthalene

The invention belongs to the technical field of organic synthesis, and particularly discloses a method for preparing 1-cyclopropylnaphthalene. According to the method disclosed by the invention, 1-naphthylacetophenone is adopted as a raw material, and 1-cyclopropylnaphthalene can be simply and conveniently synthesized through reduction, dehydration, cyclization and reductive dehalogenation. The method has the advantages of cheap and easily available raw materials, no need of precious metals or dangerous organic metal reagents, low raw material cost, convenient production, environmental protection and safety, and is very suitable for industrial production. The method disclosed by the invention has the advantages of high yield in each step, few byproducts and easiness in purification.

Lesinurad analogue and its preparation method and medical use

The invention relates to a lesinurad analog as shown in the general formula (I), its preparation method, a pharmaceutical composition containing the derivative and an application of the pharmaceutical composition used as a therapeutic agent, especially as a medicine for treating hyperuricemia and gout, wherein definition of each substituent group in the general formula (I) is as the same as definition in the specification.

Method for synthesizing aromatic compound by coupling palladium/imidazole salt with nitroaromatic hydrocarbon and boric acid compound (by machine translation)

The invention discloses a method, for coupling a palladium/imidazole salt with a nitroaromatic hydrocarbon and a boric acid compound to synthesize an aromatic compound. The method comprises: in organic solvent, taking nitroaromatic hydrocarbon and boric acid compound as substrate, palladium/imidazole salt as a catalyst, carrying out coupling reaction under the action of alkali, and carrying out post-treatment to obtain the aromatic compound. The method is simple, easy to store, low in price, relatively low in ligand consumption, high in product yield, good in substrate applicability, and suitable for alkyl boronic acid. The process of the invention can be used to synthesize a series of aromatic compounds, for example. The compound has wide application value in the fields of pesticides, medicines, materials and the like. (by machine translation)