250330-71-3Relevant articles and documents
Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains
Buijsman, Rogier C.,Basten, Jan E. M.,Dreef-Tromp, Cornelia M.,Van Der Marel, Gijsbert A.,Van Boeckel, Constant A. A.,Van Boom, Jacques H.
, p. 1881 - 1890 (2007/10/03)
The synthesis of three heparin analogues (i.e. compounds VI-VIII) having perphosphorylated thrombin binding domains (TBDs) is reported. These compounds were tested in vitro for their antithrombin III (ATIII)-mediated anti-Xa and antithrombin activities. Conjugates VI and VIII show a remarkable increase in antithrombin activity compared to the structurally related conjugates with persulfated TBDs (i.e. compounds IV and V), whereas compound VII displays a diminished activity.