250355-93-2Relevant academic research and scientific papers
A second-generation total synthesis of (+)-phorboxazole A
Smith III, Arnos B.,Razler, Thomas M.,Ciavarri, Jeffrey P.,Hirose, Tomoyasu,Ishikawa, Tomoyasu,Meis, Regina M.
, p. 1192 - 1200 (2008/09/17)
(Chemical Equation Presented) A highly convergent second-generation synthesis of (+)-phorboxazole A has been achieved. Highlights of the synthetic approach include improved Petasis-Ferrier union/rearrangement conditions on a scale to assemble multigram qu
Phorboxazole synthetic studies. 1. Construction of a C(3-19) subtarget exploiting an extension of the Petasis-Ferrier rearrangement
Smith III, Amos B.,Verhoest, Patrick R.,Minbiole, Kevin P.,Lim, John J.
, p. 909 - 912 (2008/02/09)
(equation presented) In this, the first of two Letters, we outline our overall strategy for the total synthesis of phorboxazoles A (1) and B (2), rare oxazole-containing macrolides possessing extraordinary antimitotic activity, and describe the assembly o
