25057-77-6

Basic information

• Product Name: 1,2-DIMETHYL-PIPERAZINE
• Synonyms: 1,2-DIMETHYL-PIPERAZINE;1,2-DIMETHYL-PIPERAZINE >98%;1,2-dimethylpiperazine(SALTDATA: 2HCl 0.7H2O)
• CAS NO: 25057-77-6
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.19
• Product Categories: Piperaizine;Heterocycles
• Mol File: 25057-77-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 42°C/6mm
• Flash Point: 44.9°C
• Appearance: /
• Density: 0.855g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.31±0.40(Predicted)
• CAS DataBase Reference: 1,2-DIMETHYL-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIMETHYL-PIPERAZINE(25057-77-6)
• EPA Substance Registry System: 1,2-DIMETHYL-PIPERAZINE(25057-77-6)

Safety Data

• Hazardous Substances Data: 25057-77-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

Upstream product

• 109-07-9 (RS)-2-methylpiperazine 
• 120737-59-9 3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 741287-32-1 tert-butyl 3,4-dimethylpiperazine-1-carboxylate 
• 29906-47-6 1-benzyl-2-methylpiperazin-3-one 
• 29906-54-5 1-benzyl-2-methylpiperazine 
• 92699-31-5 4-benzyl-3-methyl-piperazine-1-carboxylic acid ethyl ester 
• 90152-49-1 3-methylpiperazine-1-carboxylic acid ethyl ester 
• 23936-11-0 3-methylpiperazin-2-one 
• 114649-94-4 3,4-dimethyl-piperazine-1-carboxylic acid ethyl ester 

Downstream Products

• 1035271-03-4 ethyl 4-(3,4-dimethylpiperazin-1-yl)benzoate 
• 1035270-08-6 N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-5-(3,4-dimethylpiperazin-1-yl)pyrazine-2-carboxamide 
• 1035270-09-7 N-[5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-yl]-5-(3,4-dimethylpiperazin-1-yl)pyrazine-2-carboxamide 
• 1207455-35-3 8-(4-((3,4-dimethylpiperazin-1-yl)methyl)phenyl)-9-(4-fluorophenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 
• 1422389-63-6 C₁₉H₂₁ClN₄O₃ 

Relevant articles and documents

INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING

The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Studies in Potential Filaricides: Part 20 - Synthesis of 1,4-Disubstituted Piperazines as Diethylcarbamazine Analogs

A series of substituted 2,4-dimethylpiperazines (10-15), 1-benzyl-2-methylpiperazines (16-19), 1-substituted 3-methylpiperazines (20-25,27) and 1,4-disubstituted piperazines (28-34) have been synthesized starting from 1-benzyl-2-methylpiperazine (9) and 1