250579-91-0Relevant academic research and scientific papers
MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER
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Paragraph 0072; 0077, (2016/07/27)
Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.
AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS
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Page 65-66, (2008/06/13)
The present invention is related to azole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such azole derivatives. Said azole derivatives are modulators of the protein kinase signalling pathways, particularly the one involving c-Jun N-terminal kinase and/or Glycogen Kinase Synthase 3. The present invention is furthermore related to novel azole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1 -C6 alkyl; A is 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group.
Synthesis of Some Coumarin Derivatives as Potential Laser Dyes
Elnagdi, M. H.,Abdallah, S. O.,Ghoneim, K. M.,Ebied, E. M.,Kassab, K. N.
, p. 375 - 384 (2007/10/03)
With a view to extend the tunability range and maximum output of the coumarin series of dyes, fifteen new 3-substituted 7-hydroxycoumarins emitting in the blue-green region of the visible spectrum are synthesized, and some of them showed laser activity.
