250583-08-5

Basic information

• Product Name: (2R,3S)-2-[(R)-Amino-(4-methoxy-phenyl)-methyl]-3-benzo[1,3]dioxol-5-yl-4-hydroxy-butyric acid methyl ester
• Synonyms: (2R,3S)-2-[(R)-Amino-(4-methoxy-phenyl)-methyl]-3-benzo[1,3]dioxol-5-yl-4-hydroxy-butyric acid methyl ester
• CAS NO: 250583-08-5
• Molecular Weight: 373.406
• Mol File: 250583-08-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-2-[(R)-Amino-(4-methoxy-phenyl)-methyl]-3-benzo[1,3]dioxol-5-yl-4-hydroxy-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-2-[(R)-Amino-(4-methoxy-phenyl)-methyl]-3-benzo[1,3]dioxol-5-yl-4-hydroxy-butyric acid methyl ester(250583-08-5)
• EPA Substance Registry System: (2R,3S)-2-[(R)-Amino-(4-methoxy-phenyl)-methyl]-3-benzo[1,3]dioxol-5-yl-4-hydroxy-butyric acid methyl ester(250583-08-5)

Safety Data

• Hazardous Substances Data: 250583-08-5(Hazardous Substances Data)

Upstream product

• 250583-06-3 (3R,4R,5S)-5-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-phenyl)-[1,2]oxazinane-4-carboxylic acid methyl ester 
• 250583-02-9 3-benzo[1,3]dioxol-5-yl-4-(4-chloro-benzenesulfonyloxy)-butyric acid tert-butyl ester 
• 250582-99-1 (S)-3-Benzo[1,3]dioxol-5-yl-4-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester 
• 250583-03-0 (S)-3-Benzo[1,3]dioxol-5-yl-4-[1-(4-methoxy-phenyl)-meth-(E)-ylideneaminooxy]-butyric acid tert-butyl ester 
• 250583-05-2 (S)-3-Benzo[1,3]dioxol-5-yl-4-[1-(4-methoxy-phenyl)-meth-(E)-ylideneaminooxy]-butyric acid methyl ester 
• 179390-12-6 (4''S)-isopropyl-2''-oxazolidino-N-(3',4'-methylenedioxy) phenylacetate 
• 250583-01-8 3-benzo[1,3]dioxol-5-yl-4-hydroxy-butyric acid tert-butyl ester 
• 250261-64-4 2-(3,4-Methylenedioxyphenyl)acetic pivalic anhydride 
• 250583-00-7 (S)-2-Benzo[1,3]dioxol-5-yl-succinic acid 4-tert-butyl ester 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 

Downstream Products

• 195733-43-8 Atrasentan hydrochloride 
• 250583-09-6 (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid methyl ester 

Relevant articles and documents

Preparation of endothelin antagonist ABT-627

An enantioselective synthesis of ABT-627 is described. The key transformation is a diastereoselective 6-endo-trig cyclization to produce a 3,4,5-trisubstituted-1,2-oxazine which is ring contracted to the 2,3,4-tri-substituted-pyrrolidine core of ABT-627.