2506-20-9

Usage

Uses

Used in Pharmaceutical Industry:
L-Tetrahydropalmatine hydrochloride is used as a therapeutic agent for neurological and psychiatric disorders due to its analgesic, anxiolytic, and sedative properties.
Used in Treatment of Drug Addiction and Withdrawal:
L-Tetrahydropalmatine hydrochloride is used as an alleviating agent for symptoms of drug addiction and withdrawal, potentially aiding in the management of substance abuse disorders.
Used in Research and Development:
L-Tetrahydropalmatine hydrochloride is used as a subject of ongoing research for its potential as a treatment for conditions such as anxiety, depression, and substance abuse disorders, with its effects on neurotransmitter systems in the brain being a key area of investigation.

Upstream product

• 483-14-7 tetrahydropalmatine 

Relevant academic research and scientific papers

Bioactive isoquinoline alkaloids from Corydalis saxicola

Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)-2,9-dihydroxyl-3,11-dimethoxy-1,10- dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC 50 values of less than 10M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.