250602-54-1Relevant articles and documents
Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives
Imoto, Hiroshi,Imamiya, Eikoh,Momose, Yu,Sugiyama, Yasuo,Kimura, Hiroyuki,Sohda, Takashi
, p. 1349 - 1357 (2002)
A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in genetically obese and diabetic KKAy mice. Several of the compounds showed strong antidiabetic activity, including functional potency at peroxisome proliferator-activated receptor (PPAR)-γ. (Z)-2-[4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino]-2-(4- phenoxyphenyl)acetic acid (25) significantly reduced plasma glucose (33%, p0.01) and plasma triglycelide levels (43%, p0.01) even at a dosage of 0.001% in diet. Pharmacokinetic analyses of 25 are also reported.
Highly efficient sequential N,N,C-trialkylation of α-N-acyloxyimino esters
Mizota, Isao,Maeda, Tatsuya,Shimizu, Makoto
supporting information, p. 5793 - 5799 (2015/08/03)
α-N-Acyloxyimino esters serve as highly efficient substrates for the N,N,C-trialkylation reaction that can introduce various patterns of nucleophiles at the imino nitrogen and carbon atoms to synthesize N,N-dialkylated and N,N,C-trialkylated α-amino esters in moderate to high yields.
