25063-69-8

Basic information

• Product Name: 5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione
• Synonyms: 5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione;5-((6-methoxypyridin-3-ylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 25063-69-8
• Molecular Formula: C₁₃H₁₄N₂O₅
• Molecular Weight: 278.26066
• EINECS: -0
• Mol File: 25063-69-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione(25063-69-8)
• EPA Substance Registry System: 5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione(25063-69-8)

Safety Data

• Hazardous Substances Data: 25063-69-8(Hazardous Substances Data)

Usage

General Description

5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione is a chemical compound with the molecular formula C13H16N2O5. It is a pyridine derivative with a dioxane ring structure. 5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione has potential biological activity due to its amino and methylidene functional groups. It may be used in pharmaceutical research as a building block for the synthesis of new compounds with potential therapeutic applications, or as a reference standard in analytical chemistry. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 6628-77-9 6-methoxy-pyridin-3-ylamine 
• 2033-24-1 cycl-isopropylidene malonate 
• 122-51-0 orthoformic acid triethyl ester 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 23443-25-6 6-methoxy-1,5-naphthyridin-4-ol 
• 915976-85-1 8-bromo-7-chloro-2-methoxy-1,5-naphthyridine 
• 943025-80-7 methyl [3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]acetate 
• 1073495-87-0 3-chloro-6-methoxy-1,5-naphthyridin-4-ol 
• 1075259-77-6 3-fluoro-6-methoxy-1,5-naphthyridin-4-ol 
• 724788-70-9 8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine 
• 1415415-01-8 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine 
• 952059-81-3 tert-butyl 2-[2-methoxy-4-(6-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetate 
• 952059-80-2 2-[2-methoxy-4-(6-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetic acid 
• 952059-87-9 methyl 2-[3-methoxy-5-(6-methoxy-1,5-naphthyridin-4-yloxy)pyridin-2-yl]acetate 

Relevant articles and documents

SIX-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND AND USES THEREOF SERVING AS PROTEIN RECEPTOR KINASE INHIBITOR

Provided are a preparation and applications of a six-membered fused with six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases.

Process for Manufacturing a Naphthyridine Derivative

The invention relates to a process and synthetic intermediates that can be used for manufacturing the compound of formula (1-6) which is a synthetic intermediate useful in the preparation of antibiotic compounds.

A one-pot diazotation-fluorodediazoniation reaction and fluorine gas for the production of fluoronaphthyridines

Several synthetic routes to 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine (1) are presented, and their suitability for scale-up is discussed. The way of introducing the fluorine atom is crucial. Early routes start from commercially available fluorinated building blocks or employ F+ reagents like SelectFluor and delivered up to 70 kg of 7-fluoro-2-methoxy-1,5-naphthyridine (18). To prepare for larger scales, the focus turned to the use of HF or elemental fluorine, both one of the cheapest sources of fluorine. The first method, a one-pot diazotation-fluorodediazoniation with 6-methoxy-1,5- naphthyridin-3-amine (9) in HF gave the fluorinated naphthyridine 18 in high yield and purity without isolation of the unstable diazonium salt, the latter being a severe drawback of the related Balz-Schiemann protocol. The second method relies on the use of fluorine gas for a surprisingly selective ortho-fluorination of 6-methoxy-1,5-naphthyridin-4-ol (10).