25065-00-3

Usage

Type

Chemical compound and derivative of pyridine

Uses

Synthesis of pharmaceuticals and agrochemicals

Biological activities

Antidiabetic, anti-inflammatory, and central nervous system effects

Inhibition

Potent inhibitor of aldehyde oxidase enzyme

Potential applications

Treatment of neurodegenerative diseases and cancer

Fields of use

Medicine, agriculture, and drug development.

InChI:InChI=1/C6H7NO/c1-7-4-2-3-6(8)5-7/h2-5H,1H3

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 74-88-4 methyl iodide 
• 4685-07-8 3-hydroxy-N-methylpyridinium ion 
• 7500-05-2 3-hydroxy-1-methylpyridin-1-ium iodide 
• 7295-78-5 3-hydroxy-N-methylpyridinium chloride 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 125217-79-0 N-methyl-6β-(phenylsulphonyl)-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 125217-80-3 N-methyl-6α-fluoro-6β-(phenylsulphonyl)-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 139730-35-1 N-methyl-(1R,5R,6S,R_S)-6-(p-tolylsulphinyl)-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 139730-37-3 N-methyl-(1S,5S,6R,R_S)-6-(p-tolylsulphinyl)-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 139730-38-4 N-methyl-(1R,5R,6R,R_S)-6-(p-tolylsulphinyl)-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 139730-35-1 (1S,5S,6S)-8-Methyl-6-(toluene-4-sulfinyl)-8-aza-bicyclo[3.2.1]oct-3-en-2-one 
• 139730-35-1 (1R,5R,6S)-8-Methyl-6-(toluene-4-sulfinyl)-8-aza-bicyclo[3.2.1]oct-3-en-2-one 
• 139730-35-1 (1S,5S,6R)-8-Methyl-6-(toluene-4-sulfinyl)-8-aza-bicyclo[3.2.1]oct-3-en-2-one 
• 3554-74-3 3-Hydroxy-1-methylpiperidine 
• 125217-79-0 endo-6-benzenesulfonyl-8-methyl-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 125217-81-4 (1S,2R,5S,6R)-6-Benzenesulfonyl-8-methyl-8-aza-bicyclo[3.2.1]octan-2-ol 
• 125217-81-4 (1S,2S,5S,6R)-6-Benzenesulfonyl-8-methyl-8-aza-bicyclo[3.2.1]octan-2-ol 
• 125217-84-7 (1S,2R,5S,6R)-6-Benzenesulfonyl-6-fluoro-8-methyl-8-aza-bicyclo[3.2.1]octan-2-ol 
• 125217-84-7 (1S,2S,5S,6R)-6-Benzenesulfonyl-6-fluoro-8-methyl-8-aza-bicyclo[3.2.1]octan-2-ol 

Relevant academic research and scientific papers

Aryne cycloaddition with 3-oxidopyridinium species

The [3 + 2] cycloaddition of arynes with 3-oxidopyridinium species is examined using the Kobayashi benzyne precursor. The reaction affords a bicyclo[3.2.1] skeleton under mild conditions. A [7 + 2] cycloaddition mode with a subsequent pyridine ring-opening event has also been observed.

On the preparation of some phospholipid analogues

Several structural analogues of the biocompatible diacyl glycerol phosphatidylcholine family have been prepared. Considerable variation in structure is allowed without impairing the desirable biocompatible properties. In particular, derivatives in which the fatty ester link is replaced by ether links and in which the central glycerol group is replaced by simple variants such as the symmetrical tris(hydroxymethyl)ethane group retain biocompatible properties. The Royal Society of Chemistry 2000.

Solvatochromism in Pure Solvents: Effects of the Molecular Structure of the Probe

The following solvatochromic probes were synthesized: l-methyl-8-oxyquinolinium betaine (QB), sodium i-methyl-8-oxycuinolinium betaine-5-sulphonate (QBS), and l-rnelhyl-3-oxypyridinium betaine (PB). Their solvatochromic behavior in 28 protic and aprotic solvents was investigated, and the data compared to those of 2,6-diphenyl-4-(2,4,6-triphenyI-l-pyridmio)-l-phenolate, (RB). Solvent polarity scales based on QB, QBS, and PB correlate linearly with the ET(30) scale of RB. The Taft-Kamlet-Abboud equation satisfactorily applies to the solvatochromic data of RB, QB, QBS and PB. The multipararneter regression coefficients (a) and (s) of the above mentioned equation show that the sensitivity of the probe to solvent dipolarity/polarizability, arid hydrogen bond donation is clearly dependent on its molecular structure. This dependence was tested for a total of 26 probes of widely different structures. It is shown that this is a generai behavior, i.e., log a and s ' are linearly dependent on the p/C, and the dipole moment of the probe, respectively. VCH Verlagsgesellschaft mbH, 1996.

Structure of the Calystegines: New alkaloids of the nortropane family

Three new alkaloids have been isolated from Calystegia sepium; their structures have been established from their 1H and 13C N.M.R. spectra, and confirmed by the synthesis of model compounds.

1,3-Dipolar Character of Six-membered Aromatic Rings. Part 56. The Cycloadditions of Acetylenes and 3-Oxidopyridinium Betaines

Cycloaddition of dimethyl acetylenedicarboxylate with a variety of 1-substituted 3-oxidopyridinium betaines yields novel furan cycloadducts.Methyl phenylpropiolate reacts similarly with the activated 1--3-oxidopyridinium betai

Proximate Charge Effects. 4. Heats of Reaction and Enthalpies of Solvent Transfer of Reactants and Products in the Deprotonation of 2-Hydroxy-N,N,N-trimethylanilinium Ion and 3-Hydroxy-N-methylpyridinium Ion

Heats of neutralization, +ROH + OH- -> +RO- + H2O in water, in aqueous ethanol, and in aqueous dimethyl sulfoxide, were measured for two rigid choline analogues, namely, +ROH = 2-hydroxy-N,N,N-trimeth