25068-14-8Relevant articles and documents
HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT
-
, (2022/02/02)
The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and can thus be usefully used in the treatment of lung cancer.
Microwave-assisted hydrothermal synthesis, characterization and catalytic performance of Fe2(MoO4)3 in the selective oxidation of propene
Hidalgo,Tonelli,Burel,Aouine,Millet
, p. 36 - 44 (2019/05/27)
A method for the simple and efficient microwave radiation-assisted hydrothermal synthesis of Fe2(MoO4)3 has been developed. Several factors such as pH, addition rate, molybdenum precursor, type of solvent and various other microwave synthesis parameters are studied. The catalysts were characterized using X-ray diffraction, scanning electron microscopy, M?ssbauer spectroscopy and specific surface area measurements. The results show that different morphologies can be obtained, depending on the conditions under which the iron molybdate is prepared. Nevertheless, in all cases the solid particles appear to be covered by an amorphous oxide layer, which is less rich in iron than in the case of a crystallized oxide layer. The presence of this amorphous layer was revealed on all facets of the molybdate, with approximately the same composition and thickness. In an effort to evaluate the relationship between the morphology of iron molybdate particles and their catalytic properties, several samples exhibiting different morphology were tested for the oxidation of propene to acrolein. These samples were tested for the oxidation of propene to acrolein. The catalysts with platelets morphology and exhibiting larger surface of (100) planes appeared more active. This was attributed to a faster re-oxidation due to the preferential diffusion of oxygen anions in the bulk structure channels perpendicular to these planes.
Mesoporous silica supported phosphotungstic acid catalyst for glycerol dehydration to acrolein
Wang, Zhiheng,Liu, Licheng
, p. 55 - 64 (2020/10/20)
Conversion of glycerol to acrolein is a useful reaction for value-added application of biodiesel-derived glycerol and bioenergy development. The high-performance solid acid catalyst is essential to this dehydration reaction. In this paper, tungsten-based heteropolyacids (HPA) were supported on non-ordered mesoporous silica (MSU-x) to increase their dispersion and used as catalysts for glycerol dehydration to acrolein. Aiming to reveal the surface structure of HPA and resulting acidic properties, as well as the relationship between acidic properties and dehydration activity, different loadings of H3PW12O40 were supported on MSU-x (10–50 wt%) and the catalysts were characterized by X-ray diffraction (XRD), BET, SEM/TEM, UV–vis diffuse reflectance spectra (DRS), Raman and FT-IR techniques. Their acidic properties were studied by NH3-Temperature Programmed Desorption (NH3-TPD) and Pyridine adsorption methods. The molecular structure and dispersion of H3PW12O40 supported on the catalysts was revealed. The Keggin unit preserved well but with different hydration level for various loadings. The total acid concentration and respective Br?nsted/Lewis acid identification were calculated. The acrolein yield increased with H3PW12O40 loading until 30 wt% and showed less change with higher loadings. Based on the correlation of acrolein formation rate with acidic properties, the active role of Br?nsted acid and the cooperative role of Br?nsted/Lewis acid sites for glycerol dehydration to acrolein were discussed. This work provides new insight into the structure evolution of heteropolyacids and the catalyst design for the glycerol to acrolein.
