250682-07-6

Basic information

• Product Name: ethyl 3-(morpholin-4-yl)-5-(trifluoromethyl)benzoate
• Synonyms: Benzoic acid, 3-(4-morpholinyl)-5-(trifluoromethyl)-, ethyl ester
• CAS NO: 250682-07-6
• Molecular Formula: C₁₄H₁₆F₃NO₃
• Molecular Weight: 303.2769
• Mol File: 250682-07-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 403.558°C at 760 mmHg
• Flash Point: 197.865°C
• Density: 1.26g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.489
• CAS DataBase Reference: ethyl 3-(morpholin-4-yl)-5-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(morpholin-4-yl)-5-(trifluoromethyl)benzoate(250682-07-6)
• EPA Substance Registry System: ethyl 3-(morpholin-4-yl)-5-(trifluoromethyl)benzoate(250682-07-6)

Safety Data

• Hazardous Substances Data: 250682-07-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 250682-12-3 ethyl 3-fluoro-5-(trifluoromethyl)benzoate 
• 250682-06-5 N-(3-amino-4-methylphenyl)-3-morpholino-5-trifluoromethylbenzamide 

Downstream Products

• 250682-08-7 3-(4-morpholin-4-yl)-5-trifluoromethylbenzoic acid 

Relevant articles and documents

AMIDE DERIVATIVES

The invention concerns amide derivatives of Formula (Ia) wherein X is -NHCO- or -CONH-; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R2 is a group

BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS

The invention concerns amide derivatives of formula (I) wherein R 3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R 1 and R 2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R 4 is a basic group such as amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, di-[(1-6C)alkyl]amino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; and Q 2 is a group such as heteroaryl, heteroaryloxy or heteroaryl-(1-6C)alkoxy which is optionally substituted; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

Synthesis of meta-substituted aniline derivatives by nucleophilic substitution

Substitution by amines of fluorobenzenes containing a meta- substituted electron withdrawing group (EWG), in DMSO at 100 °C over 60 h gave meta-substituted aniline derivatives in isolated yields of up to 98%. The scope of the reaction is explored in terms of reaction conditions and substrates. It is postulated that facile meta-substitutions are facilitated through field stabilisation of the intermediate anion by EWG substituents.