250685-44-0 Usage
Uses
8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid Methyl Ester is a potent nociceptin receptor agonist.
Biological Activity
Potent non-peptide agonist for the NOP receptor (EC 50 = 305 nM, K i = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 250685-44-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,0,6,8 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 250685-44:
(8*2)+(7*5)+(6*0)+(5*6)+(4*8)+(3*5)+(2*4)+(1*4)=140
140 % 10 = 0
So 250685-44-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H29N3O3/c1-33-25(31)19-29-20-30(24-9-3-2-4-10-24)27(26(29)32)13-15-28(16-14-27)18-21-11-12-22-7-5-6-8-23(22)17-21/h2-12,17H,13-16,18-20H2,1H3
250685-44-0Relevant articles and documents
1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
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, (2008/06/13)
The present invention relates to the use of small organic compounds acting as opioid receptor ligands for the treatment of vasomotor disturbances. In particular the present invention relates to the use of triaza-spiro compounds of formula wherein R1
