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250694-19-0

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250694-19-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 250694-19-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,0,6,9 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 250694-19:
(8*2)+(7*5)+(6*0)+(5*6)+(4*9)+(3*4)+(2*1)+(1*9)=140
140 % 10 = 0
So 250694-19-0 is a valid CAS Registry Number.

250694-19-0Upstream product

250694-19-0Downstream Products

250694-19-0Relevant articles and documents

Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity

Giannessi, Fabio,Pessotto, Pompeo,Tassoni, Emanuela,Chiodi, Piero,Conti, Roberto,De Angelis, Francesco,Dell'Uomo, Natalina,Catini, Roberto,Deias, Roberto,Tinti, Maria Ornella,Carminati, Paolo,Arduini, Arduino

, p. 303 - 309 (2007/10/03)

The synthesis and pharmacological activity of reversible CPT I inhibitors as potential antiketotic and antidiabetic drugs are reported. Such inhibitors constitute a series of enantiomerically pure aminocarnitine derivatives having the general formula (CH3)3N+CH2CH(ZR) CH2COO- (with Z = ureido, carbamate, sulfonamide, and sulfamide moieties; R = C7-C14 linear alkyl chains). A primary pharmacological screening based on the evaluation of CPT I activity in intact rat liver (L-CPT I) mitochondria revealed the best activity for the (R) forms of ureidic derivative 17 (ZR = NHCONHR, R = C14), sulfonamidic derivative 7 (ZR = NHSO2R, R = C12), and sulfamidic derivative 9 (ZR = NHSO2NHR, R = C11). The IC50 values are 1.1, 0.7, and 0.8 μM, respectively. For the carbamic derivative 11 (ZR = NHCOOR, R = C8), an IC50 of 9.5 μM was observed. In addition, an extraordinarily high selectivity toward the liver isoform with respect to the heart isoform (muscle-CPT I M-CPT I) was found for the ureidic compound 17 (IC50(M-CPT I) vs IC50(L-CPTI) = 39.4), as well as for other ureidic or carbamic compounds. Diabetic db/db mice treated orally with 17 and 7 for 45 days at a dose of 50 mg/kg twice a day showed a good reduction of serum glucose levels with respect to the untreated db/db mice (p a potential antiketotic and antidiabetic drug.

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