250714-79-5

Basic information

• Product Name: 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI
• Synonyms: 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI;N-(4-Fluorobenzenesulphonyl)valine;2-(4-Fluorobenzenesulphamido)-3-methylbutyricacid97%
• CAS NO: 250714-79-5
• Molecular Formula: C₁₁H₁₄FNO₄S
• Molecular Weight: 275.2965632
• Mol File: 250714-79-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 159～161℃
• Appearance: /
• CAS DataBase Reference: 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI(250714-79-5)
• EPA Substance Registry System: 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI(250714-79-5)

Safety Data

• Hazardous Substances Data: 250714-79-5(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorobenzenesulphamido)-3-methylbutyric acid, also known as FSBMBA, is a chemical compound with the molecular formula C11H14FNO3S. It is a derivative of the non-steroidal anti-inflammatory drug, meclofenamic acid, and is believed to have similar analgesic and anti-inflammatory properties. FSBMBA has been studied for its potential use in treating various inflammatory and pain-related conditions. Its chemical structure features a fluorobenzenesulphonamide group and a 3-methylbutyric acid group, which are thought to contribute to its pharmacological activity. While further research is needed to fully understand its therapeutic potential, FSBMBA represents a promising avenue for the development of new pharmaceuticals targeting pain and inflammatory disorders.

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 516-06-3 D,L-valine 

Downstream Products

• 287406-76-2 2-[(4-but-2-ynyloxy-benzenesulfonyl)-methyl-amino]-3-methyl-butyric acid 
• 1494-30-0 1-fluoro-4-((4-methylbenzyl)sulfonyl)benzene 

Relevant articles and documents

Silver-Catalyzed C(sp3)-H Sulfonylation for the Synthesis of Benzyl Sulfones Using Toluene Derivatives and α-Amino Acid Sulfonamides

We describe a simple and practical protocol for the synthesis of benzyl sulfones using readily available toluene derivatives and α-amino acid sulfonamides. The reaction proceeds to afford a broad range of benzyl sulfones in moderate to high yields under silver catalysis. The mechanism possibly involves a Minisci-type formation of α-aminoalkyl radical, homolytic cleavage of a N-S bond to generate a sulfonyl radical, and coupling of sulfonyl radical with a benzyl radical formed via hydrogen abstraction by sulfate anion radical. The practicality of the present reaction is demonstrated by a gram-scale synthesis and one-step synthesis of anticancer-active compound. The mechanism studies are conducted using radical scavengers and deuterated toluene.

ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS

Compound of the formula (B) are useful in treating disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.