250718-98-0Relevant academic research and scientific papers
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists
Xu, Ruo,Li, Shengjian,Paruchova, Jaroslava,McBriar, Mark D.,Guzik, Henry,Palani, Anandan,Clader, John W.,Cox, Kathleen,Greenlee, William J.,Hawes, Brian E.,Kowalski, Timothy J.,O'Neill, Kim,Spar, Brian D.,Weig, Blair,Weston, Daniel J.
, p. 3285 - 3299 (2007/10/03)
Melanin concentrating hormone (MCH) receptor antagonists have been proposed as potential treatments of obesity. MCH receptor antagonists with a biphenylamine subunit have been reported previously at Schering-Plough. Herein, we report the discovery of bicy
Antidepressant heterocyclic compounds
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, (2008/06/13)
Compounds of formula I are useful antidepressant agents demonstrating potent inhibition of 5-HT reuptake. Z is selected from among various phenyl and hetaryl moieties while Y is benzyl or indolyl.
A convenient synthesis to N-aryl-substituted 4-piperidones
Tortolani, David R.,Poss, Michael A.
, p. 1261 - 1262 (2008/02/09)
(matrix presented) A general and efficient procedure for the synthesis of N-aryl-substituted 4-piperidones was developed. The general methodology was applied to the synthesis of several different N-aryl-4-piperidones utilizing an expedient two-step proces
