2(3H)-Phenanthrenone, 4,4a,4b,5,6,7,8,8a,9,10-decahydro-4b,8,8-trimethyl-1-propyl-, (4aR,4bS,8aS)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.
The CAS Registry Mumber 250720-36-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,0,7,2 and 0 respectively; the second part has 2 digits, 3 and 6 respectively. Calculate Digit Verification of CAS Registry Number 250720-36: (8*2)+(7*5)+(6*0)+(5*7)+(4*2)+(3*0)+(2*3)+(1*6)=106 106 % 10 = 6 So 250720-36-6 is a valid CAS Registry Number.
250720-36-6SDS
SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition
250720-36-6Relevant academic research and scientific papers
The synthesis and antibacterial activity of totarol derivatives. Part 1: Modifications of ring-C and pro-drugs
Evans, Gary B.,Furneaux, Richard H.,Gravestock, Michael B.,Lynch, Gregory P.,Scott, G.Kenneth
, p. 1953 - 1964 (2007/10/03)
A series of analogues of, and potential pro-drugs derived from, the potent antibacterial diterpene totarol (1) were synthesized in order to elucidate the minimum structural requirements for antibacterial activity and to seek compounds with good bioavailability in vivo. These analogues varied in the structural features of their aromatic rings and the prodrugs were O-glycosylated derivatives. They were tested in vitro against three Gram-positive bacteria: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus (MRSA); and against the Gram-negative multi-drug-resistant Klebsiella pneumoniae. None of the analogues was more potent than totarol itself, which is effective against these Gram-positive bacteria at MIC values of 7 μM. The results were evaluated in terms of a structure-activity relationship and this showed that a phenolic moiety was essential for potent antibacterial activity. Amongst the pro-drugs, totaryl α-D-mannopyranoside (22) proved the most active in vitro (MIC 18 μM). The in vivo antibacterial activities of compounds 1, 22 and totarol β-lactoside (23) were assessed in a mouse model of infection, but they were found to be ineffective. Compounds 1 and 22 were shown to be cytotoxic towards proliferating human cell cultures, CH 2983, HeLa, and MG 63, but only at concentrations of > 30 μM.
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