250727-23-2

Upstream product

• 100-44-7 benzyl chloride 
• 97035-89-7 4-amino-3-mercapto-5-(o-aminophenyl)-1,2,4-triazole 
• 1904-58-1 anthranilic acid hydrazide 
• 203268-81-9 2-(2-aminophenyl)-5-mercapto-1,3,4-oxadiazole 

Downstream Products

• 1211760-03-0 3-(2-aminophenyl)-N-[(4-chlorophenyl)methylene]-5-(benzylthio)-4H-1,2,4-triazol-4-amine 
• 1211760-08-5 3-(2-aminophenyl)-N-[(4-methoxyphenyl)methylene]-5-(benzylthio)-4H-1,2,4-triazol-4-amine 

Relevant academic research and scientific papers

Combinatorial approach: Identification of potential antifungals from triazole minilibraries

Employing basic principles of solution phase combinatorial chemistry, a solution phase combinatorial synthesis and screening of mini libraries of 1,2,4-triazole derivatives has been carried out. 6 x 6 indexed mini libraries were synthesized comprising of 36 compounds. The libraries were analyzed by liquid chromatography - mass spectrometry - mass spectrometry (LC - MS - MS) analysis. All the synthesized mini libraries were screened for antifungal activity and by deconvolution methodology leads for every fungi used for study were identified. The leads were synthesized individually and screened for activity. The antifungal activity of individually synthesized leads was improved as anticipated, in comparison with that of any of the mini libraries. Springer Science+Business Media, LLC 2010.

Studies on organophosphorus compounds. Synthesis and reactions of 1,2,4-triazolo(4,3-d)-1,3,4,2-benzo-oxadiazaphosphopine and triazaphosphopine derivatives

2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulphide (Lawesson's Reagent, LR) reacted with 4-amino-3-mercapto-5-(o-hydroxyphenyl and/or o-aminophenyl)-1,2,4-triazoles (1a and 2a) in boiling acetonitrile to afford s-triazolo(4,3-d)-1,3,4,2-b