250735-69-4

Upstream product

• 250735-61-6 Methoxy-acetic acid (E)-(1R,2R)-1-((S)-1-benzyloxycarbonylamino-2-methanesulfonyloxy-ethyl)-2-(tert-butyl-dimethyl-silanyloxy)-pent-3-enyl ester 
• 250735-62-7 Methoxy-acetic acid (E)-(1R,2R)-2-acetoxy-1-((S)-1-benzyloxycarbonylamino-2-methanesulfonyloxy-ethyl)-pent-3-enyl ester 
• 250735-63-8 Methoxy-acetic acid (E)-(1R,2R)-2-acetoxy-1-((R)-1-benzyloxycarbonylamino-2-iodo-ethyl)-pent-3-enyl ester 
• 250735-64-9 (S)-2-[(E)-(1R,2R)-2-Acetoxy-1-(2-methoxy-acetoxy)-pent-3-enyl]-aziridine-1-carboxylic acid benzyl ester 
• 250735-67-2 (S)-2-[(1R,2S)-2-Acetoxy-1-(2-methoxy-acetoxy)-3-oxo-propyl]-aziridine-1-carboxylic acid benzyl ester 
• 213454-13-8 Methanesulfonic acid (E)-(2S,3R,4R)-2-benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-hept-5-enyl ester 
• 213454-11-6 (S)-4-[(E)-(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-pent-3-enyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 213454-12-7 [(E)-(1S,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-1-hydroxymethyl-hex-4-enyl]-carbamic acid benzyl ester 
• 117833-92-8 (4S)-3-benzyloxycarbonyl-2,2-dimethyloxazolidine-4-carbaldehyde 

Downstream Products

• 207679-37-6 (S)-2-((E)-(1R,2S)-2-Acetoxy-4-acetylamino-3-bromo-1-hydroxy-4-methoxycarbonyl-but-3-enyl)-aziridine-1-carboxylic acid benzyl ester 
• 207679-38-7 (S)-2-((E)-(1R,2S)-2-Acetoxy-4-acetylamino-3-bromo-4-methoxycarbonyl-1-trimethylsilanyloxy-but-3-enyl)-aziridine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of naturally occurring antitumor agents: Stereocontrolled synthesis of the azabicyclic ring system of the azinomycins

Full details of the synthesis of the fully elaborated aziridino[1,2-a]pyrrolidine substructure 2 of the antitumor agents azinomycins A and B are reported. Stereoselective bromination of dehydroamino acid 4 provided control of olefin configuration in the f