250757-34-7Relevant academic research and scientific papers
Modular Total Synthesis of Farnesyl Analogues of Cell Wall Precursors Lipid i and II Containing the Staphylococcus aureus Pentaglycine Bridge Modification
Wingen, Lukas M.,Rausch, Marvin,Schneider, Tanja,Menche, Dirk
, p. 10206 - 10215 (2020/09/03)
A scalable and modular total synthesis of 3-lipid I and 3-lipid II was accomplished by a novel route involving an efficient solid phase synthesis of the peptide fragment and an effective chemoenzymatic attachment of the second sugar moiety. The generality of this route was further documented by the synthesis of an analogue bearing the pentaglycine interpeptidic bridge modification characteristic for the human pathogen Staphylococcus aureus.
The kinetic characterization of Escherichia coli MurG using synthetic substrate analogues
Ha, Sha,Chang, Emmanuel,Lo, Mei-Chu,Men, Hongbin,Park, Peter,Ge, Min,Walker, Suzanne
, p. 8415 - 8426 (2007/10/03)
Bacterial resistance to existing antibiotics poses a serious threat to human health. Because the peptidoglycan surrounding bacterial cells is essential for survival, the enzymes involved in peptidoglycan biosynthesis are attractive targets for the design
