250778-96-2

Basic information

• Product Name: (2 S)-2-[(4-phenoxyphenoxy)methyl]oxirane
• Synonyms: (2 S)-2-[(4-phenoxyphenoxy)methyl]oxirane
• CAS NO: 250778-96-2
• Molecular Weight: 242.274
• Mol File: 250778-96-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2 S)-2-[(4-phenoxyphenoxy)methyl]oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: (2 S)-2-[(4-phenoxyphenoxy)methyl]oxirane(250778-96-2)
• EPA Substance Registry System: (2 S)-2-[(4-phenoxyphenoxy)methyl]oxirane(250778-96-2)

Safety Data

• Hazardous Substances Data: 250778-96-2(Hazardous Substances Data)

Upstream product

• 831-82-3 4-Phenoxyphenol 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 

Downstream Products

• 391901-34-1 (2 S)-1-[(4-aminophenethyl)amino]-3-(4-phenoxyphenoxy)-2-propanol 
• 391901-36-3 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-2-hydroxy-3-(4-phenoxyphenoxy)propyl]carbamate 
• 391901-35-2 tert-butyl 4-aminophenethyl[(2 S)-2-hydroxy-3-(4-phenoxyphenoxy)propyl]carbamate 

Relevant articles and documents

SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

Potent, selective aminothiazolidinediones agonists of the human β3 Adrenergic receptor

A cloned human β3 adrenergic receptor assay was used to identify potent and selective β3 agonists. The thiazolidinedione moiety has been identified as a new pharmacophore for the human β3 adrenergic receptor. The versatility of the thiazolidinedione pharmacophore was demonstrated in both the arylethanolamine and phenylpropanolamine families of β3 agonists, where potent and selective compounds have been synthesized. Thiazolidinedione 20, a potent and selective human β3 agonist, increased thermogenesis and lowered plasma glucose levels in the db/db mice.