250778-97-3Relevant academic research and scientific papers
Jacobsen-type enantioselective hydrolysis of aryl glycidyl ethers. 31P NMR analysis of the enantiomeric composition of oxiranes
Bredikhin,Strunskaya,Novikova,Azancheev,Sharafutdinova,Bredikhina
, p. 213 - 218 (2004)
The enantioselective partial hydrolysis of a number of racemic aryl glycidyl ethers in the presence of chiral Co(salen)-catalyst was studied. The enantiomeric composition of the isolated (R)-aryl glycidyl ethers was analyzed by 31P NMR using optically active substituted 2-chloro-1,3,2- dioxaphospholanes. A synthesis of β-adrenoblocking agents (S)-toliprolol and (S)-moprolol based on the simultaneously obtained (S)-3-aryloxypropane-1,2- diols was proposed.
Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes
Peukert, Stefan,Jacobsen, Eric N.
, p. 1245 - 1248 (2008/02/09)
(matrix presented) The kinetic resolution of epoxides with phenols catalyzed by a polymer-supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries. The corresponding 1-aryloxy-2-alcohols are obtained i
