2508-79-4 Usage
Uses
Ethyl methyldopate hydrochloride is Antihypertensive.
Brand name
Aldomet (Merck).
General Description
Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter.
Clinical Use
Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.
Check Digit Verification of cas no
The CAS Registry Mumber 2508-79-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,0 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2508-79:
(6*2)+(5*5)+(4*0)+(3*8)+(2*7)+(1*9)=84
84 % 10 = 4
So 2508-79-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO4/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8/h4-6,14-15H,3,7,13H2,1-2H3/t12-/m0/s1
2508-79-4Relevant articles and documents
A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo
Qiu, Jin-Mei,Qin, Chang-Feng,Wu, Shen-Gen,Ji, Tong-Ying,Tang, Guo-Tao,Lei, Xiao-Yong,Cao, Xuan,Xie, Zhi-Zhong
, p. 108 - 114 (2021)
E-DRS is a novel salvianolic acid A (SAA) analog, which was synthesized from resveratrol (RES) and methyldopate. Its structure is similar to that of SAA, but the 3′,4′-dihydroxy-trans-stilbene group and the ester structure in SAA were replaced by the RES
