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Ethyl methyldopate hydrochloride, also known as Methyldopate hydrochloride or L-3-(3,4-dihydroxyphenyl)-2-methylalanine ethyl ester hydrochloride (Aldomet ester hydrochloride), is a pharmaceutical compound with hypotensive properties. It functions by inhibiting the outflow of sympathetic vasoconstrictor impulses from the brain, effectively lowering blood pressure. Early research suggested that its hypotensive action might be due to its peripheral properties as a decarboxylase inhibitor or a false transmitter. It is commercially available under the brand name Aldomet, manufactured by Merck.

2508-79-4

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2508-79-4 Usage

Uses

Used in Pharmaceutical Industry:
Ethyl methyldopate hydrochloride is used as an antihypertensive agent for the treatment of high blood pressure. It helps in managing and reducing the risk of cardiovascular events associated with hypertension by effectively lowering blood pressure levels.

Clinical Use

Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.

Check Digit Verification of cas no

The CAS Registry Mumber 2508-79-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,0 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2508-79:
(6*2)+(5*5)+(4*0)+(3*8)+(2*7)+(1*9)=84
84 % 10 = 4
So 2508-79-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO4/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8/h4-6,14-15H,3,7,13H2,1-2H3/t12-/m0/s1

2508-79-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate,hydrochloride

1.2 Other means of identification

Product number -
Other names METHYLDOPATE HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2508-79-4 SDS

2508-79-4Downstream Products

2508-79-4Relevant academic research and scientific papers

A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo

Qiu, Jin-Mei,Qin, Chang-Feng,Wu, Shen-Gen,Ji, Tong-Ying,Tang, Guo-Tao,Lei, Xiao-Yong,Cao, Xuan,Xie, Zhi-Zhong

, p. 108 - 114 (2021)

E-DRS is a novel salvianolic acid A (SAA) analog, which was synthesized from resveratrol (RES) and methyldopate. Its structure is similar to that of SAA, but the 3′,4′-dihydroxy-trans-stilbene group and the ester structure in SAA were replaced by the RES

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