2508-86-3

Usage

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.

InChI:InChI=1/C9H8N2O.ClH/c10-8-5-6-11(12)9-4-2-1-3-7(8)9;/h1-6,10,12H;1H/b10-8+;

Upstream product

• 56-57-5 4-nitroquinoline-N-oxide 
• 578-68-7 4-aminoquinoline 
• 4637-59-6 4-Chloroquinoline N-oxide 
• 2669-36-5 4-quinolyl azide N-oxide 
• 1613-37-2 Quinoline N-oxide 

Downstream Products

• 22615-00-5 3-bromoquinoline N-oxide 
• 21236-85-1 quinoline-4-carbonitrile 1-oxide 
• 4637-59-6 4-Chloroquinoline N-oxide 
• 80947-25-7 2-chloroquinoline-4-amine 

Relevant academic research and scientific papers

Concerning Model Metabolites of the Carcinogen 4-Nitroquinoline 1-Oxide. Reactivity and Solvolytic Behavior of 1-Hydroxy-4-(acetoxyimino)-1,4-dihydroquinoline

1-Hydroxy-4-(acetoxyimino)-1,4-dihydroquinoline is obtained quantitatively by reaction of 1-acetoxy-4-(acetoxyimino)-1,4-dihydroquinoline with piperidine in dimethyl sulfoxide.Spectroscopic results establish that this monoacetate exists preferentially as

PHOTOLYSIS AND THERMOLYSIS OF QUINOLYL AND ISOQUINOLYL AZIDES IN ETHANETHIOL

3-Quinolyl azides (8), upon either irradiation or heating in ethanethiol, gave 3-amino-4-ethylthioquinolines (9), presumably via a radical process.Similarly, 4-isoquinolyl azides (11) gave 3-ethyl-thio- (12) and/or 1-ethylthio-4-aminoisoquinolines (13), and 8-quinolyl azide (17) gave 7-ethylthio- (18) and 5-ethylthio-8-aminoquinoline (19), while 4-quinolyl azides (15) gave only 8-aminoquinolines (16).

KINETICS OF N-OXIDATION OF COMPOUNDS OF THE QUINOLINE SERIES AND ISOMERIC BENZOQUINOLINES BY PERBENZOIC ACID IN CHLOROFORM AND AQUEOUS DIOXANE

The kinetics of the N-oxidation with perbenzoic acid of 15 derivatives of quinoline and benzoquinoline in chloroform and 19 compounds in 50percent aqueous dioxane at 20, 25, 30, and 35 deg C were subjected to a comparative study.The rate constants, parameters of Arrhenius equation, and the activation energies for the N-oxidation of the indicated monoazines were determined.A scale of the reactivities of derivatives of the quinoline series and benzoquinolines was calculated within the framework of general perturbation theory.