25102-85-6

Upstream product

• 68043-67-4 4-[(Z)-3-((Ξ)-3-methyl-3H-benzothiazol-2-ylidene)-triaz-1-enyl]-benzonitrile 
• 58364-73-1 4-[(E)-3-((Ξ)-3-methyl-3H-benzothiazol-2-ylidene)-triaz-1-enyl]-benzonitrile 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 98234-74-3 α-Trichloromethylsulfonyl-5-nitro-2-furaldehyde 4-Cyanophenylhydrazone 
• 79643-59-7 9-(4-cyanophenylazo)julolidine 
• 145664-16-0 2-[(4-Cyano-phenyl)-hydrazono]-3-oxo-hexanoic acid ethyl ester 
• 23501-84-0 C₁₈H₁₇N₃O₄S 
• 141536-16-5 λ⁴-bis(4-cyanophenyl)dichloroselane 
• 1072120-02-5 9-(p-cyanophenylselanyl)triptycene 
• 340137-11-3 6-(N-methyl-N-(4-(4'-cyanophenylazo)phenyl)amino)hexyl methacrylate 

Relevant academic research and scientific papers

An investigation of the synthesis of vilazodone

A novel synthetic route toward vilazodone is described by using 4-cyanoaniline and 5-bromo-2-hydroxybenzaldehyde as starting materials, with an overall yield of 24% and 99% purity. First, the intermediate (3-(4-chlorobutyl)-1H-indole-5-carbonitrile) is synthesized via diazotization of 4-cyanoaniline, followed by Fischer indole cyclization with 6-chlorohexanal. Subsequently, another intermediate, 5-(piperazin-1-yl)benzofuran-2-carboxamide, is generated via aromatic nucleophilic substitution of 5-bromobenzofuran-2-carboxamide with piperazine. Finally, vilazodone is obtained via nucleophilic substitution of the above two key intermediates by treatment with Et3N/K2CO3. In comparison to the original process, this route avoids the use of expensive and toxic reagents and resolves issues such as safety, environmental concerns, and high costs.

PROCESS FOR THE SYNTHESIS OF ARYLDIAZONIUM SALTS USING NITROGEN OXIDES IN OXYGEN-CONTAINING GAS STREAMS, ESPECIALLY FROM INDUSTRIAL WASTE GASES

The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

Photoresponsive behavior of two well-defined azo polymers with different electron-withdrawing groups on push-pull azo chromophores

Two well-defined methacrylate-based azo polymers bearing strong push-pull azo chromophores were synthesized by RAFT polymerization. The polymers contain cyano and carboxyl as electron-withdrawing groups at 4-positions of the azo chromophores. The polymers

NLO properties of poled azocarbazole-epoxy composites

Azocarbazole dyes are organic molecules that have already shown potential in nonlinear optical applications in host-guest systems. These molecules should be covalently bound to a host polymer network. This can be easily achieved if the host polymer is an

ANTI-HIV COMPOUNDS

Thiazole derivatives represented by Formula (I) are disclosed, where R1, R2, R3, A, X, Y, Z, R6 and R7 are disclosed herein. These thiazole derivatives and pharmaceutical compositions comprising these derivatives are useful in the treatment of HIV mediated diseases and conditions.

OPEN CHAIN NITROGEN COMPOUNDS. PART XIII. 1-ARYL-3-ARYLTHIOMETHYL-3-METHYLTRIAZENES AND 3-(ARYLAZO)-1,3-THIAZOLIDINES

Reaction of 3-acetoxymethyl-1-aryl-3-methyltriazenes with sodium thiophenolate or thiocresolate in anhydrous dimethylformamide affords a new series of 3-arylthiomethyltriazenes (2).Ar-S-CH2-NMe-N=N-Ar'.These triazenes are remarkably labile in aqueous buff

Open-chain nitrogen compounds. Part IV. Synthesis of 5-hydroxy-1,2,3-triazoles from 1-aryl-3-(ethoxycarbonylmethyl)triazenes: a new route to α-diazo-N-arylacetamides

A series of triazenes of type ArN=N-NH-CH2CO2Et, N-arylazoglycine ethyl esters, have been prepared by coupling the arene diazonium salt, ArN2+*X-, with ethyl glycinate, NH2CH2CO2Et; an electron-withdrawing substituent, e.g.NO2, CN, CO2R, and Cl, in the ortho or para position of the aryl group is essential for efficient coupling.The p-substituted arylazoglycine ethyl esters cyclize when treated with alcoholic potassium hydroxide to afford the potassium salts of the 1-aryl-5-hydroxy-1,2,3-triazoles, which can be obtained free by acidification of the potassium salt solution with acetic acid.Reaction of the potassium salts with acetic anhydride yields the 1-aryl-5-acetoxy-1,2,3-triazoles.The 5-hydroxytriazoles, when heated in ethanol, rearrange to α-diazoacetanilides, ArNH*COCHN2.The diazoamides can be obtained in low yield directly from the triazenes by prolonged refluxing in ethanol. o-Substituted aryltriazenes do not cyclize under the same conditions but fragment to the arylamine.

1,2,3-Triazabutadienes. XIV. Investigations into the Acidic Cleavage of the Z-E-Isomeric 1-Aryl-3-- and 1-Aryl-3--triazenes

The rate of the acid cleavage of the Z-E-isomeric 1-aryl-3-- and 1-aryl-3--triazenes 1 - 5 is investigated in dependence on the substituents in the aryl and benzo residue.The Z-isomer