25102-85-6

Basic information

• Product Name: Benzenediazonium, 4-cyano-, chloride
• CAS NO: 25102-85-6
• Molecular Formula: C7H4N3.Cl
• Molecular Weight: 165.582
• Mol File: 25102-85-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenediazonium, 4-cyano-, chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenediazonium, 4-cyano-, chloride(25102-85-6)
• EPA Substance Registry System: Benzenediazonium, 4-cyano-, chloride(25102-85-6)

Safety Data

• Hazardous Substances Data: 25102-85-6(Hazardous Substances Data)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 58364-73-1 4-[(E)-3-((Ξ)-3-methyl-3H-benzothiazol-2-ylidene)-triaz-1-enyl]-benzonitrile 
• 68043-67-4 4-[(Z)-3-((Ξ)-3-methyl-3H-benzothiazol-2-ylidene)-triaz-1-enyl]-benzonitrile 

Downstream Products

• 145664-16-0 2-[(4-Cyano-phenyl)-hydrazono]-3-oxo-hexanoic acid ethyl ester 
• 98234-79-8 α-Trichloromethylsulfonyl-5-nitro-2-furaldehyde N-Methyl-4-cyanophenylhydrazone 

Relevant articles and documents

An investigation of the synthesis of vilazodone

A novel synthetic route toward vilazodone is described by using 4-cyanoaniline and 5-bromo-2-hydroxybenzaldehyde as starting materials, with an overall yield of 24% and 99% purity. First, the intermediate (3-(4-chlorobutyl)-1H-indole-5-carbonitrile) is synthesized via diazotization of 4-cyanoaniline, followed by Fischer indole cyclization with 6-chlorohexanal. Subsequently, another intermediate, 5-(piperazin-1-yl)benzofuran-2-carboxamide, is generated via aromatic nucleophilic substitution of 5-bromobenzofuran-2-carboxamide with piperazine. Finally, vilazodone is obtained via nucleophilic substitution of the above two key intermediates by treatment with Et3N/K2CO3. In comparison to the original process, this route avoids the use of expensive and toxic reagents and resolves issues such as safety, environmental concerns, and high costs.

Photoresponsive behavior of two well-defined azo polymers with different electron-withdrawing groups on push-pull azo chromophores

Two well-defined methacrylate-based azo polymers bearing strong push-pull azo chromophores were synthesized by RAFT polymerization. The polymers contain cyano and carboxyl as electron-withdrawing groups at 4-positions of the azo chromophores. The polymers

ANTI-HIV COMPOUNDS

Thiazole derivatives represented by Formula (I) are disclosed, where R1, R2, R3, A, X, Y, Z, R6 and R7 are disclosed herein. These thiazole derivatives and pharmaceutical compositions comprising these derivatives are useful in the treatment of HIV mediated diseases and conditions.