251096-97-6 Usage
General Description
1-(3-(Trifluoromethyl)benzenesulfonyl)proline is a chemical compound with the molecular formula C14H14F3NO4S. It is an amino acid derivative and proline analog that contains a benzene ring with a trifluoromethyl group and a sulfonamide group. 1-(3-(TRIFLUOROMETHYL)BENZENESULFONYL)PROLINE has been studied for its potential as a proline-dependent enzyme inhibitor and as a building block for the synthesis of pharmaceuticals and other bioactive compounds. It is also used in research and development in the field of medicinal chemistry for the design of new drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 251096-97-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,1,0,9 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 251096-97:
(8*2)+(7*5)+(6*1)+(5*0)+(4*9)+(3*6)+(2*9)+(1*7)=136
136 % 10 = 6
So 251096-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H12F3NO4S/c13-12(14,15)8-3-1-4-9(7-8)21(19,20)16-6-2-5-10(16)11(17)18/h1,3-4,7,10H,2,5-6H2,(H,17,18)
251096-97-6Relevant articles and documents
α-Amino Acid Sulfonamides as Versatile Sulfonylation Reagents: Silver-Catalyzed Synthesis of Coumarins and Oxindoles by Radical Cyclization
Kanyiva, Kyalo Stephen,Hamada, Daisuke,Makino, Sohei,Takano, Hideaki,Shibata, Takanori
, p. 5905 - 5909 (2018)
We developed a silver-catalyzed strategy for the generation of sulfonyl radicals from sulfonamides derived from α-amino acids. The reaction proceeded via a decarboxylation, N–S bond cleavage and radical cyclization sequence and allows the difunctionalization of alkynes and the synthesis of 3-sulfonylated coumarins. The reaction tolerated a broad scope of substrates and functional groups and could be extended to the synthesis of oxindoles and an isoquinolinedione by the capturing of the sulfonyl radical with an alkene moiety. Moreover, the proposed mechanism was supported experimentally and by DFT calculations.
