25115-75-7

Basic information

• Product Name: 4-CYANO-4-(4-CHLOROPHENYL)CYCLOHEXANONE
• Synonyms: 4-CYANO-4-(4-CHLOROPHENYL)CYCLOHEXANONE;1-(4-chlorophenyl)-4-oxocyclohexanecarbonitrile
• CAS NO: 25115-75-7
• Molecular Formula: C₁₃H₁₂ClNO
• Molecular Weight: 233.697
• Mol File: 25115-75-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CYANO-4-(4-CHLOROPHENYL)CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-4-(4-CHLOROPHENYL)CYCLOHEXANONE(25115-75-7)
• EPA Substance Registry System: 4-CYANO-4-(4-CHLOROPHENYL)CYCLOHEXANONE(25115-75-7)

Safety Data

• Hazardous Substances Data: 25115-75-7(Hazardous Substances Data)

Usage

General Description

4-CYANO-4-(4-CHLOROPHENYL)CYCLOHEXANONE is a chemical compound with the molecular formula C15H15NO. It is a cyclohexanone derivative with a cyanogroup and a 4-chlorophenyl group attached to the cyclohexane ring. 4-CYANO-4-(4-CHLOROPHENYL)CYCLOHEXANONE is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various pharmaceutical compounds and heterocyclic compounds. It has also been studied for its potential pharmacological properties and is of interest in the development of new drugs and chemical substances. Additionally, it may have applications in other areas such as material science and agrochemical research.

Upstream product

• 56326-94-4 methyl 5-cyano-5-(4-chlorophenyl)-2-oxocyclohexanecarboxylate 

Downstream Products

• 61749-06-2 8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 65619-02-5 4-cyano-4-(p-tolyl)cyclohexanone, ethylene ketal 
• 37408-81-4 2-[4-(4-Chloro-phenyl)-4-cyano-cyclohex-1-enyl]-propionic acid 
• 37408-82-5 2-[4-(4-Chloro-phenyl)-4-cyano-cyclohex-1-enyl]-propionic acid ethyl ester 

Relevant articles and documents

DI(HETERO)ARYLCYCLOHEXANE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula (I), in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula (I), their use and pharmaceutical compositions comprising them.

4-Amino-4-phenylcyclohexanone ketal compositions and process of use

A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.

Butyrophenones as hypotensive agents. Derivatives of 4 aryl 4 (hydroxymethyl)cyclohexylamine

The preparation of butyrophenone derivatives of 4 aryl 4 (hydroxymethyl) cyclohex 1 ylamines starting from the corresponding 4 cyano 4 phenylcyclohexan 1 ones is described. Substitution was varied in both rings; both isomers of 4 phenyl 4 (hydroxymethyl)cyclohex 1 ylamine were characterized. Those derivatives which carried p fluoro substitution on the butyrophenone exhibited hypotensive activity in the rat with diminished CNS activity compared to compounds lacking the hydroxymethyl group. The effect of substitution on the 4 aryl ring is discussed.