2512-24-5

Basic information

• Product Name: N-tert-butylbenzenesulfonamide
• Synonyms: N-(tert-Butyl)benzenesulphonamide
• CAS NO: 2512-24-5
• Molecular Formula: C₁₀H₁₅NO₂S
• Molecular Weight: 213.3
• Product Categories: blocks;Sulfonamides
• Mol File: 2512-24-5.mol
• Article Data: 40

Chemical Properties

• Melting Point: 77-78 °C(Solv: ethanol (64-17-5))
• Boiling Point: 313.6 °C at 760 mmHg
• Flash Point: 143.5 °C
• Appearance: /
• Density: 1.125 g/cm³
• Vapor Pressure: 0.000492mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.00±0.50(Predicted)
• CAS DataBase Reference: N-tert-butylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butylbenzenesulfonamide(2512-24-5)
• EPA Substance Registry System: N-tert-butylbenzenesulfonamide(2512-24-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 2512-24-5(Hazardous Substances Data)

Usage

General Description

N-tert-butylbenzenesulfonamide, also known as N-Tert-Butyl Benzenesulfonamide, is a chemical compound with the molecular formula C10H15NO2S. It is a sulfonamide derivative and is commonly used as an additive in polymers, resins, and coatings to improve their processing and performance properties. N-tert-butylbenzenesulfonamide is also utilized as a plasticizer in polyvinyl chloride (PVC) and other plastics, as well as a lubricant and anti-wear additive in industrial fluids. It acts as a heat stabilizer and flow modifier, which makes it useful in various applications such as adhesives, sealants, and lubricants. Additionally, it can function as an intermediate in the synthesis of other organic compounds. However, exposure to N-tert-butylbenzenesulfonamide should be limited, as it is considered to be a low-to-moderate priority substance for further research and regulation due to its potential environmental and health impacts.

InChI:InChI=1/C10H15NO2S/c1-10(2,3)11-14(12,13)9-7-5-4-6-8-9/h4-8,11H,1-3H3

Upstream product

• 98-10-2 benzenesulfonamide 
• 1634-04-4 tert-butyl methyl ether 
• 1663-39-4 tert-Butyl acrylate 
• 20487-40-5 tert-butyl propionate 
• 75-65-0 tert-butyl alcohol 
• 75-64-9 tert-butylamine 
• 98-09-9 benzenesulfonyl chloride 
• 108-98-5 thiophenol 

Downstream Products

• 430476-07-6 N-tert-butyl-2-(1-hydroxy-indan-1-yl)-benzenesulfonamide 
• 98-10-2 benzenesulfonamide 
• 53440-57-6 3-phenylbenzo[d]isothiazole-1,1-dioxide 
• 92080-32-5 2-(2-hydroxyethyl)-N-(1,1-dimethylethyl)benzenesulfonamide 
• 200054-73-5 N-tert-butyl-2-ethylthio-benzenesulfonamide 
• 914672-41-6 C₂₆H₃₂N₂O₄S 
• 29104-99-2 2-tert-butylsulfamoyl-benzoic acid 

Relevant articles and documents

Structurally Diverse Synthesis of Five-, Six-, and Seven-Membered Benzosultams through Electrochemical Cyclization

We have developed a metal- and oxidant-free approach to structurally diverse synthesis of benzosultams from aryl sulfonamides through an electrochemical cyclization. Upon variation of the ortho substituent on aryl sulfonamides, five-, six-, and seven-memb

Copper-Catalyzed Intermolecular Functionalization of Unactivated C(sp3)-H Bonds and Aliphatic Carboxylic Acids

Intermolecular functionalization of C(sp3)-H bonds and aliphatic carboxylic acids enables the efficient synthesis of high value-added organic compounds from readily available starting materials. Although methods involving hydrogen atom transfer have been developed for such functionalization, these methods either work for only activated C(sp3)-H bonds or bring in a narrow set of functional groups. Here we describe a Cu-catalyzed process for the diverse functionalization of both unactivated C(sp3)-H bonds and aliphatic carboxylic acids. The process is enabled by the trapping of alkyl radicals generated through hydrogen atom abstraction by arylsulfonyl-based SOMO-philes, which introduces a large array of C, N, S, Se, and halide-based functional groups. The chemoselectivity can be switched from C-H functionalization to decarboxylative functionalization by matching the bond dissociation energy of the hydrogen atom transfer reagent with that of the target C-H or O-H bond.

Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, we report an environmentally benign electrochemical method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chemicals. The transformation is completely driven by electricity, does not require any sacrificial reagent or additional catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility.