251307-65-0

Basic information

• Product Name: isopropyl (R)-<(2'R,5'R)-2',5'-bis(2''-naphthylethynyl)pyrrolidinylcarbonyloxy>phenylacetate
• CAS NO: 251307-65-0
• Molecular Weight: 591.706
• Mol File: 251307-65-0.mol

Chemical Properties

• CAS DataBase Reference: isopropyl (R)-<(2'R,5'R)-2',5'-bis(2''-naphthylethynyl)pyrrolidinylcarbonyloxy>phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl (R)-<(2'R,5'R)-2',5'-bis(2''-naphthylethynyl)pyrrolidinylcarbonyloxy>phenylacetate(251307-65-0)
• EPA Substance Registry System: isopropyl (R)-<(2'R,5'R)-2',5'-bis(2''-naphthylethynyl)pyrrolidinylcarbonyloxy>phenylacetate(251307-65-0)

Safety Data

• Hazardous Substances Data: 251307-65-0(Hazardous Substances Data)

Upstream product

• 580-13-2 2-bromonaphthalene 
• 251307-64-9 isopropyl (R)-(chloroformyloxy)phenylacetate 
• 89015-27-0 (R)-α-hydroxyphenylacetic acid iso-propyl ester 

Relevant articles and documents

Efficient synthesis of enantiomerically pure trans-2,5-bis(arylethynyl)pyrrolidines. A new entry into C2-symmetric chiral secondary amines

A new class of C2-symmetric pyrrolidine derivatives bearing arylethynyl groups at the 2,5-positions has been synthesized in enantiomerically pure form from 1,7-octadiyne-3,6-diol in five steps. Some notable features of the synthesis are: (i) the formation of a separable diastereomeric mixture of pyrrolidine carbamates using a newly prepared chiral chloroformate; and (ii) the development of a new method for the deprotection of the carbamate via a novel SmI2-promoted electron transfer process.