251319-25-2Relevant academic research and scientific papers
Preparation of chiral hydroxy carbonyl compounds and diols by ozonolysis of olefinic isoborneol and fenchol derivatives: Characterization of stable ozonides by 1H-, 13C-, and 17O-NMR and electrospray ionization mass spectrometry
Kostova, Kalina,Dimitrov, Vladimir,Simova, Svetlana,Hesse, Manfred
, p. 1385 - 1399 (1999)
The allylic and homoallylic alcohols 1-8, prepared from (+)-camphor and (-)-fenchone, were ozonized in Et2O at -78°and treated with Et3N or LiAIH4 to give the chiral hydroxy carbonyl compounds 9-16 and the diols 17- 24, respectively (Scheme 1). In the case of the diols 19 and 24, the formation of new chiral centers proceeded with high diastercoselectivity. These diols were prepared highly diastereoselectively also by LiAIH4 reduction of the hydroxy carbonyl compounds 11 and 16a, respectively (Scheme 2). The absolute configuration of the new chiral centers in 19 and 24 was determined by X-ray and NMR methods. The ozonization of compounds 2, 3, 7, and 8 provided the relatively stable hydroxy-substituted 1,2,4-trioxolane derivatives (ozonides) 37-40 (Scheme 5) which were characterized by 1H- and 13C-NMR spectra, ESI-MS, and natural-abundance 17O-NMR spectra.
