251324-84-2Relevant academic research and scientific papers
Stereoselective synthesis of cis-p-menth-8-ene-1,7-diol, cis-p-menthane-1,7-diol, and cis-p-menthane-1,7,8-triol
Kobler, Christoph,Effenberger, Franz
, p. 2783 - 2787 (2007/10/03)
The natural products cis-p-mentharie-1,7-diol (cis-IV), cis-p-menth-8-ene-1,7-diol (cis-I) and cis-p-menthane-1,7,8-triol (cis-II) are obtained starting from the corresponding cis-cyanohydrins, cis-2 and cis-7, respectively, by chemical transformation of
Hydroxynitrile lyase-catalyzed addition of HCN to 4-substituted cyclohexanones: Stereoselective preparation of tetronic acids
Effenberger, Franz,Roos, Juergen,Kobler, Christoph,Buehler, Holger
, p. 671 - 679 (2007/10/03)
The addition of HCN to 4-alkylcyclohexanones 1 to give cyanohydrins 2 is strongly catalyzed by hydroxynitrile lyases (HNLs). With PaHNL, from bitter almond, trans-addition occurs almost exclusively, yielding trans-2. With MeHNL, from cassava, cis-addition
cis-trans selectivity of enzyme-catalyzed additions to 4-substituted cyclohexanones - Correlation with the Prelog/Ringold model of enzymatic hydrogenation
Effenberger, Franz,Roos, Juergen,Kobler, Christoph
, p. 1876 - 1879 (2007/10/03)
The choice of enzyme is decisive: for the enzyme-catalyzed addition of HCN to 4-substituted cyclohexanones 1, highly selective biocatalysts are available that allow control to yield the cis or the trans addition product 2. Modeling of the S enzyme - subst
