25140-24-3

Upstream product

• 6002-31-9 t-butylphenylphosphine 
• 74-88-4 methyl iodide 
• 594-19-4 tert.-butyl lithium 
• 76195-60-3 C₁₄H₁₆NP 
• 2181-42-2 trimethylsulphonium iodide 
• 325801-01-2 (tert-butyl-methyl-phosphinothioyl)-benzene 
• 29949-69-7 tert-butylchlorophenylphosphane 
• 917-54-4 methyllithium 
• 21448-79-3 t-butylmethylphenylphosphine oxide 
• 644-97-3 Dichlorophenylphosphine 
• 20685-01-2 Methylphenylamino-phenylchlorphosphin 
• 21448-79-3 (R_P)-tert-butylphenylmethylphosphine oxide 

Downstream Products

• 6002-50-2 Phenyl-tert.-butyl-methyl-(p-benzhydryl-phenyl)-phosphoniumjodid 
• 6057-81-4 Methyl-tert.-butyl-phenyl-desyl-phosphonium-jodid 
• 21448-79-3 t-butylmethylphenylphosphine oxide 
• 325801-01-2 (tert-butyl-methyl-phosphinothioyl)-benzene 
• 38802-08-3 (S)-(-)-tert-butylmethylphenylphosphine oxide 
• 1150290-56-4 Pt(η5-C5Me5)(PMe(t-Bu)Ph)I 
• 21448-79-3 (R_P)-tert-butylphenylmethylphosphine oxide 

Relevant academic research and scientific papers

Synthesis and application of P-stereogenic phosphines as superior reagents in the asymmetric aza-Wittig reaction

(Chemical Equation Presented) A wide variety of P-stereogenic aryldialkylphosphines were prepared in enantioenriched form by a systematic diversification of the (-)-sparteine-mediated dynamic kinetic resolution of racemic lithiophosphine-boranes reported

Highly efficient reduction of tertiary phosphine oxides and sulfides with amine-assisted aluminum hydrides under mild conditions

Reduction of tertiary phosphine oxides and sulfides into the corresponding phosphines with amine-assisted aluminum hydrides has been studied. The method is characterized by mild conditions, short reaction time, high efficiency, and expanded substrate scope. The new method is an alternative to the currently used methods of reducing phosphine oxides or recycling phosphines engaged in organic reactions.

Reduction of tertiary phosphine oxides with DIBAL-H

(Chemical Equation Presented) The reduction of tertiary phosphine oxides (TPOs) and sulfides with diisobutylaluminum hydride (DIBAL-II) has been studied in detail. An extensive solvent screen has revealed that hindered aliphatic ethers, such as MTBE, are optimum for this reaction at ambient temperature. Many TPOs undergo considerable reduction at ambient temperature and then stall due to inhibition. 31P and 13C NMR studies using isotopically labeled substrates as well as competition studies have revealed that the source of this inhibition is tetraisobutyldialuminoxane (TIBAO), which builds up as the reaction proceeds. TIBAO selectively coordinates the TPO starting material, preventing further reduction. Several strategies have been found to circumvent this inhibition and obtain full conversion with this extremely inexpensive reducing agent for the first time. Practical reduction protocols for these critical targets have been developed.

Synthesis of P-stereogenic phosphorus compounds. Asymmetric oxidation of phosphines under appel conditions

Racemic phosphines are converted into enantioenriched phosphine oxides via a synthetically simple, but theoretically interesting, oxidation procedure in good enantiomeric excess (up to 80%) and excellent yields (>95%). These phosphine oxides can be oxidatively coupled to provide easy access to enantiopure DiPAMPO analogues. Particularly attractive aspects of this procedure are the operational simplicity and the low cost required to synthesize these high value compounds. Copyright

Radical-based reduction of phosphine sulfides and phosphine selenides by (Me3Si)3SiH

Tris(trimethylsilyl)silane reacts with phosphine sulfides and phosphine selenides under free radical conditions to give the corresponding phosphines in good yields. Stereochemical studies on P-chiral phosphine sulfides show these reductions proceed with retention of configuration. (C) 2000 Elsevier Science Ltd.

A novel synthesis of unsymmetrical tertiary phosphines: Selective nucleophilic substitution on phosphorus(III)

A new synthesis of unsymmetrical tertiary phosphines has been developed employing selective, sequential alkylation of chloroaminophospnines by Grignard and organolithium reagents.

Dimethylsulfonium Methylide as a Methylating Agent for Three-Coordinate Phosphorus Derivatives

Dimethylsulfonium methylide methylates primary alkyl- and arylphosphines and some secondary phosphines containing at least one substituent that does not exhibit donating properties with respect to phosphorus to give corresponding methylphosphines in high yield. The reaction proceeds as a two-step process with initial deprotonation of the phosphine with the ylide and subsequent nucleophilic elimination of the sulfonium salts with the phosphide. The second step determines the overall reaction rate.

Phosphinegold (I) salts having antiarthritic activity

The compounds are (pyridine) (trisubstituted phosphine) gold(I) salts which have antiarthritic activity.

Tri-substituted phosphinegold(I) 1-thio-β-D-glucopyranosides

The compounds are tri-substituted phosphinegold(I) 1-thio-β-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis. Of the three substituents on the phosphine one is optionally substituted phenyl and the others are lower alkyl or lower alkoxy.