25143-69-5Relevant articles and documents
Stereoselectivity in the Darzens condensation of substituted cyclohexanones with (-)-8-phenylmenthyl α-chloroacetate
Shinohara, Yoshihiro,Ohba, Yuko,Takagi, Ryukichi,Kojima, Satoshi,Ohkata, Katsuo
, p. 9 - 12 (2007/10/03)
The Darzens condensation of 4-monosubstituted and cis-3,5-dimethyl-cyclohexanones with (-)-8-phenylmenthyl α-chloroacetate proceeded to give mixtures of trans- and cis-glycidic esters with high enolate face selectivity (≥95% de). The presence of axial met