251636-84-7

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 1871-76-7 diphenylacetic acid chloride 

Downstream Products

• 251636-86-9 4-diphenylacetylamino-1-(5'-4,4'-dimethoxytrityl-2'-deoxy-β-D-erythro-pentofuranosyl)-2-pyridone 
• 251636-85-8 4-diphenylacetylamino-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-2-pyridone 

Relevant academic research and scientific papers

Synthesis of the analogue nucleoside 3-deaza-2'-deoxycytidine and its template activity with DNA polymerase

A new synthesis of the nucleoside analogue 3-deaza-2'-deoxycytidine is described. The N3-nitrogen of dC is involved in the central hydrogen bond of a dG-dC base pair. The relative importance of hydrogen bonding as a controlling factor in the activity of DNA polymerase is examined by studying both duplex stability and template effects for this dc3C nucleoside. Duplexes containing dG-dc3C base pairs were strongly destabilized while templates containing the analogue nucleoside were found to incorporate only the complementary dG triphosphate, similar to observations with templates containing the native 2'-deoxycytidine.