251658-76-1

Basic information

• Product Name: 3-(5-ETHYL-1H-PYRAZOL-3-YL)PYRIDINE
• Synonyms: 3-(5-ETHYL-1H-PYRAZOL-3-YL)PYRIDINE;3-(5-ethyl-2H-pyrazol-3-yl)-pyridine
• CAS NO: 251658-76-1
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21
• Mol File: 251658-76-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 54-55 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 371.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.137±0.06 g/cm3(Predicted)
• PKA: 12.72±0.10(Predicted)
• CAS DataBase Reference: 3-(5-ETHYL-1H-PYRAZOL-3-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-ETHYL-1H-PYRAZOL-3-YL)PYRIDINE(251658-76-1)
• EPA Substance Registry System: 3-(5-ETHYL-1H-PYRAZOL-3-YL)PYRIDINE(251658-76-1)

Safety Data

• Hazardous Substances Data: 251658-76-1(Hazardous Substances Data)

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 622403-56-9 1-(pyridin-3-yl)-1,3-pentanedione 
• 350-03-8 methyl-3-pyridylketone 
• 554-12-1 propanoic acid methyl ester 

Downstream Products

• 251658-77-2 1-(4-nitrophenyl)-3-(3-pyridinyl)-5-ethylpyrazole 
• 622403-61-6 3-(1,5-diethyl-1H-pyrazol-3-yl)pyridine 
• 622403-66-1 3-(1,3-diethyl-1H-pyrazol-5-yl)pyridine 
• 251658-72-7 1(4-aminophenyl)-3-(pyridin-3-yl)-5-ethylpyrazole 

Relevant articles and documents

Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.

Practical synthesis of 1,3-diaryl-5-alkylpyrazoles by a highly regioselective N-arylation of 3,5-disubstituted pyrazoles with 4- fluoronitrobenzene

3-Aryl-5-alkylpyrazoles undergo a highly regioselective arylation on N-1 atom with 4-fluoronitrobenzene in the presence of base to yield the corresponding 1-(4-nitrophenyl)pyrazoles. (C) 2000 Elsevier Science Ltd.