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25173-72-2

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25173-72-2 Usage

Description

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID, also known as trimethoprim, is a monocarboxylic acid derived from propionic acid with a 3,4,5-trimethoxyphenyl substituent at the 3-position. It is a white to almost white crystalline powder and is known for its various applications in different industries.

Uses

Used in Pharmaceutical Industry:
3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID is used as an active pharmaceutical ingredient for the treatment of bacterial infections. It works by inhibiting the bacterial enzyme dihydrofolate reductase, which is essential for the synthesis of nucleic acids and proteins in bacteria, thus preventing their growth and multiplication.
Used in Veterinary Medicine:
In the veterinary field, 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID is used as an antimicrobial agent for the treatment of bacterial infections in animals. It is often combined with other antibiotics, such as sulfonamides, to enhance its effectiveness against a broader range of bacterial pathogens.
Used in Research and Development:
3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID is also used in research and development for the synthesis of various chemical compounds and as a starting material for the development of new drugs with potential applications in different therapeutic areas.
Used in Chemical Synthesis:
In the chemical industry, 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID serves as an intermediate in the synthesis of various organic compounds, including dyes, pigments, and other specialty chemicals. Its unique structure and reactivity make it a valuable building block for the creation of novel molecules with specific properties and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 25173-72-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,1,7 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 25173-72:
(7*2)+(6*5)+(5*1)+(4*7)+(3*3)+(2*7)+(1*2)=102
102 % 10 = 2
So 25173-72-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h6-7H,4-5H2,1-3H3,(H,13,14)/p-1

25173-72-2 Well-known Company Product Price

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  • Alfa Aesar

  • (L01456)  3-(3,4,5-Trimethoxyphenyl)propionic acid, 98+%   

  • 25173-72-2

  • 5g

  • 395.0CNY

  • Detail
  • Alfa Aesar

  • (L01456)  3-(3,4,5-Trimethoxyphenyl)propionic acid, 98+%   

  • 25173-72-2

  • 25g

  • 818.0CNY

  • Detail

25173-72-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4,5-trimethoxydihydrocinnamic acid

1.2 Other means of identification

Product number -
Other names 3,4,5-Trimethoxyhydrocinnamic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25173-72-2 SDS

25173-72-2Relevant articles and documents

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Gutsche,Hoyer

, p. 4285 (1950)

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Synthesis, mitochondrial localization of fluorescent derivatives of cinnamamide as anticancer agents

Yang, Kun,Li, Yuanyuan,Tang, Qun,Zheng, Lifang,He, Dian

, p. 45 - 54 (2019/03/19)

Mitochondria are considered as a therapeutic target for new drug design toward all kinds of cancer. Hence in order to enhance the dosage in mitochondrial fraction of cinnamamides, the mitochondria-targeted derivatives were designed by the incorporation of cinnamamides into a fluorophore carrier of coumarin-3-carboxamide with a 1:1 stoichiometry. Using the amide linkers, twenty-one compounds were synthesized and the cytotoxicity against a panel of cancer cells (MCF-7, Hela, HepG2, HL-60) was tested. In particular, compound 18c displayed the potent cytotoxicity toward HL-60 leukaemia cells, which could quickly and efficiently entry into HL-60 cells and specifically localize within mitochondria. And 18c preferred enrichment in HL-60 cells than in PBMC normal cells, accounting for the higher toxicity to cancer cells than to normal cells. Moreover, the dissipations of mitochondrial membrane potential and enhancement of cellular ROS level were also preceded upon 18c treatment, leading to cell cycle arrest and apoptosis/necrosis in HL-60 cells. Besides, acted as a Michael acceptor, 18c initiated a thia-Michael addition reaction toward cysteamine (1:2 stoichiometry), detecting by the UV-Vis spectrum and HRMS analysis. This could result in the blue emission of 18c in mitochondria after the procedure of cell fixation, owing to the formation of covalent bond with mitochondrial thiols. Our study reported 18c might be useful for the further development into a mitochondria-targeted anti-leukemia agent and the Michael acceptor might be a versatile functional group.

Synthesis, in vitro and in silico evaluation of diaryl heptanones as potential 5LOX enzyme inhibitors

Meka, Bharani,Ravada, Suryachandra Rao,Muthyala, Murali Krishna Kumar,Kurre, Purna Nagasree,Golakoti, Trimurtulu

, p. 408 - 421 (2018/07/13)

A new series of diaryl heptanones (12a-q) were synthesized and their structures were confirmed by its 1H, 13C NMR and Mass spectral data. These analogs were evaluated for their anti-oxidant activity and potential to inhibit 5-lipoxygenase. Compounds 12k and 12o showed potent in vitro 5-lipoxygenase enzyme inhibitory activity with IC50 values of 22.2, 21.5 μM, which are comparable to curcumin (24.4 μM). Further they also have shown significant antioxidant activity. Molecular docking studies clearly showed correlation between binding energy and potency of these compounds.

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