25178-38-5

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-2-(2-HYDROXYPHENYL)ACETIC ACID is used as a therapeutic agent for the treatment, prevention, or improvement of nonalcoholic fatty liver disease (NAFLD). Its application is based on its ability to modulate the underlying metabolic pathways and biochemical processes associated with the development and progression of NAFLD.
Used in Research and Development:
In addition to its pharmaceutical applications, 2-AMINO-2-(2-HYDROXYPHENYL)ACETIC ACID is also utilized as a research compound for studying the molecular mechanisms and pathophysiology of various diseases, particularly those related to metabolic and liver disorders. Its use in research aids in the development of novel therapeutic strategies and drug candidates for the treatment of such conditions.

InChI:InChI=1/C8H9NO3/c9-7(8(11)12)5-3-1-2-4-6(5)10/h1-4,7,10H,9H2,(H,11,12)

Upstream product

• 90-02-8 salicylaldehyde 
• 2835-06-5 phenylglycin 
• 252967-15-0 methyl 2-(2-hydroxyphenyl)glycinate 

Downstream Products

• 72006-07-6 Ethoxycarbonylamino-(2-hydroxy-phenyl)-acetic acid 
• 90-02-8 salicylaldehyde 
• 302-72-7 rac-Ala-OH 
• 55477-47-9 2-((tert-butoxycarbonyl)amino)-2-(2-hydroxyphenyl)acetic acid 

Relevant academic research and scientific papers

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Understanding of the mode of action of FeIII-EDDHA as iron chlorosis corrector based on its photochemical and redox behavior

The very low reduction potential of the chelate FeIII-EDDHA (EDDHA= ethylenediamine N,N'-bis(2-hydroxy)phenylacetic acid) makes it unreactive in photochemically or chemically induced electron transfer processes. The lack of reactivity of this c

2-HYDROXYPHENYLALKYLAMINE DERIVATIVES AND MAILLARD REACTION INHIBITORS

The present invention relates to a 2-hydroxyphenyl alkylamine derivative represented by the general formula: wherein R1, R2, R3and R4are the same or different: and each represents a hydrogen atom, a lower alkyl

HYDROXYLATION OF AROMATIC RINGS IN AN AQUEOUS SOLUTION INDUCED BY ARGON ARC PLASMA

Plasma-induced reaction in an aqueous solution of phenyl-containing amino acids resulted in the formation of several hydroxyphenyl amino acids, which was explained by the action of hydroxyl radicals generated by decomposition of water molecules by the high energy plasma.

HYDROXYLATION REACTION OF AROMATIC RINGS IN AQUEOUS SOLUTION INDUCED BY HYDROGEN-OXYGEN FLAME

It was found that direct hydroxylation of aromatic rings proceeded in aqueous solution of phenyl-containing amino acids by using hydrogen-oxygen flame and that the active species of the reaction could be considered as hydroxyl radicals generated in the burning flame.

3-Amidocoumaranones

3-Amidocoumaranones which may be substituted in the benzene ring by halo or alkyl; the compounds are obtained by treating an appropriate 2-hydroxyphenylacetic acid lactone with nitrous acid or with an ester, salt or chloride of nitrous acid in an acid med