251916-58-2Relevant academic research and scientific papers
Inhibiting prolyl isomerase activity by hybrid organic-inorganic molecules containing rhodium(II) fragments
Coughlin, Jane M.,Kundu, Rituparna,Cooper, Julian C.,Ball, Zachary T.
, p. 5203 - 5206 (2014)
A small molecule containing a rhodium(II) tetracarboxylate fragment is shown to be a potent inhibitor of the prolyl isomerase FKBP12. The use of small molecules conjugates of rhodium(II) is presented as a general strategy for developing new protein inhibi
Pipecolic acid derivatives as small-molecule inhibitors of the legionella MIP protein
Juli, Christina,Sippel, Martin,J?ger, Jens,Thiele, Alexandra,Weiwad, Matthias,Schweimer, Kristian,R?sch, Paul,Steinert, Michael,Sotriffer, Christoph A.,Holzgrabe, Ulrike
, p. 277 - 283 (2011/03/22)
The macrophage infectivity potentiator (MIP) protein is a major virulence factor of Legionella pneumophila, the causative agent of Legionnaires disease. MIP belongs to the FK506-binding proteins (FKBP) and is necessary for optimal intracellular survival a
