251918-41-9Relevant academic research and scientific papers
Condensed-purines syntheses of tetrahydro-1,4-diazepino[1,2,3-gh]purin- 2-one and hexahydro-1,4-diazocino[1,2,3-gh]purin-2-one
Suzuki, Hirokazu,Sawanishi, Hiroyuki,Yamamoto, Kenji,Miyamoto, Ken-Ichi
, p. 1322 - 1325 (2007/10/03)
1,4-Pyrimido- (2a), 1,4-diazepino- (2b), and 1,4-diazocino[1,2,3- gh]purine (2c) were designed as selective cAMP-phosphodiesterase 4 (PDE 4) inhibitors. The desired condensed-purines (2b,c) were synthesized by reaction of 7-aminoalkyl-3-propylpurine-2,4-d
