251936-50-2Relevant articles and documents
Solid-phase parallel synthesis of azarene pyrrolidinones as factor Xa inhibitors
Gong, Yong,Becker, Michael,Choi-Sledeski, Yong Mi,Davis, Roderick S.,Salvino, Joseph M.,Chu, Valeria,Brown, Karen D.,Pauls, Henry W.
, p. 1033 - 1036 (2000)
A focused library (4x14) prepared from 4-aminopyridine and 4-, 5-, and 6-azoindole templates was synthesized using 14 polymer supported 4-amido-2,3,5,6-tetrafluorophenyl (TFP) sulfonate esters inputs. Several compounds were identified as factor Xa inhibitors (IC50≤0.1 μM) helping to establish the SAR among these four series of azarene pyrrolidinones. (C) 2000 Elsevier Science Ltd. All rights reserved.