25195-60-2

Upstream product

• 3112-90-1 benzyl-methyl sulfone 
• 7697-37-2 nitric acid 
• 20277-69-4 sodium methansulfinate 
• 3958-60-9 2-nitrophenylmethyl bromide 

Downstream Products

• 25195-69-1 2-((methylsulfonyl)methyl)aniline 
• 1584220-20-1 4-(2-fluoro-4-nitrophenoxy)-N-(2-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine 
• 1584220-16-5 4-(4-amino-2-fluorophenoxy)-N-(2-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine 
• 1584219-93-1 N-(3-fluoro-4-((2-((2-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 552-16-9 ortho-nitrobenzoic acid 

Relevant academic research and scientific papers

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Discovery of anilinopyrimidines as dual inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and cellular activity

Both c-Met and VEGFR-2 are important targets for cancer therapies. Here we report a series of potent dual c-Met and VEGFR-2 inhibitors bearing an anilinopyrimidine scaffold. Two novel synthetic protocols were employed for rapid analoguing of the designed

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.

Mechanism of the Reaction of Sodium Hydroxide and Nitrobenzylsulphones

Aqueous sodium hydroxide reacts with sulphonyl>acetic acid (1) to give 4,4'-diformylazoxybenzene and 4,4'-dicarboxyazoxybenzene as the main products, while in 50percent water-dioxane medium the products are 4,4'-dihydroxymethylazoxybenzene, 4,4'-dicarboxyazoxybenzene besides 4-carboxy, 4'-hydroxymethylazoxybenzene and its isomer. 4-Nitrosobenzaldehyde is an intermediate in this reaction which via a Cannizzaro reaction gives the reaction products.Other 2-, 3- and 4-nitrobenzyl sulphones are studied.