251984-48-2

Upstream product

• 251984-43-7 (20R)-3β-Acetoxy-20-benzyloxy-5-oxo-5,6-secopregnan-6-oic acid 
• 251984-42-6 (20R)-5,6β-Dihydroxy-5α-pregnane-3β,20-diyl 3-acetate 20-benzoate 
• 251984-44-8 (20R)-3β-Acetoxy-20-benzyloxy-7-nor-5β,6α-pregnane-6,5-carbolactone 
• 251984-45-9 (20R)-7-Norpregn-5-ene-3β,20-diyl 3-acetate 20-benzoate 
• 73149-73-2 (20R)-pregn-5-ene-3β,20-diyl 3-acetate 20-benzoate 
• 251984-46-0 (20R)-7-Nor-5α-pregnane-3β,20-diyl 3-acetate 20-benzoate 

Downstream Products

• 251984-50-6 (20R)-7-Nor-5α-pregnane-3β,20-diyl 3-tosylate 20-benzoate 
• 251984-52-8 (20R)-3α-[(2-Methoxyethoxy)metoxy]-7-nor-5α-pregnan-20-yl benzoate 
• 251984-49-3 (20R)-3α-Hydroxy-7-nor-5α-pregnan-20-yl benzoate 
• 251984-51-7 (20R)-7-Nor-5α-pregnane-3α,20-diyl 20-benzoate 3-formate 

Relevant academic research and scientific papers

Epalons: Synthesis of 7-norallopregnanolone

The title compound 2 was prepared from (20R)-pregn-5-ene-3β,20-diyl 3-acetate 20-benzoate (3) via (20R)-3β-acetoxy-20-benzoyloxy-5-oxo-5,6-secopregnan-6-oic acid (5) and (20R)-3β-acetoxy-20-benzoyloxy-7-nor-5β,6α-pregnane-6,5-carbolac tone (6). An intermediate 7-norpregn-5-ene derivative - (20R)-7-norpregn-5-ene-3β,20-diyl 3-acetate 20-benzoate (7) -was hydrogenated using diimide in statu nascendi. The inversion of configuration at carbon C-3 was carried out via (20R)-7-nor-5α-pregnane-3β,20-diyl 3-tosylate 20-benzoate (12) and (20R)-7-nor-5α-pregnane-3α,20-diyl 20-benzoate 3-formate (13).