251986-10-4

Upstream product

• 88661-56-7 1-(3-bromopropyl)-2,5-pyrrolidinedione 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 6727-75-9 5-iodovaleronitrile 

Relevant academic research and scientific papers

Cyclic alkenenitriles: Chemoselective oxonitrile cyclizations

Potassium tert-butoxide triggers the chemoselective cyclization between nitrile anions and remote, enolizable carbonyl groups, despite the acidity difference favoring enolate formation and addition to the nitrile group. Domino deprotonation, cyclization,

Synthesis of 3,4-dihydro-2H-pyrido[1,2-b]isoindol-1-one and 3,4-dihydro- 2H-pyrido[1,2-b]pyrrolidin-1-one functionalized at the C-6 position by an intramolecular Horner-Wadsworth-Emmons reaction

Novel polyheterocycles were prepared from a new annellation reaction which proceeds by nucleophilic substitution followed by an intramolecular Horner-Wadsworth-Emmons reaction between imides and β-functionalized phosphonates.