252008-94-9

Basic information

• Product Name: 2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) 3-methyl ester, (3S)-
• CAS NO: 252008-94-9
• Molecular Formula: C16H21NO4
• Molecular Weight: 291.347
• Mol File: 252008-94-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) 3-methyl ester, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) 3-methyl ester, (3S)-(252008-94-9)
• EPA Substance Registry System: 2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) 3-methyl ester, (3S)-(252008-94-9)

Safety Data

• Hazardous Substances Data: 252008-94-9(Hazardous Substances Data)

Upstream product

• 115962-35-1 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 74163-81-8 L-Tic-OH 
• 74-88-4 methyl iodide 

Downstream Products

• 79815-19-3 methyl (3S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate 
• 393837-14-4 methyl (3S)-2-[(benzylamino)carbonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate 
• 929207-33-0 methyl (3S)-N-phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 183958-71-6 tert-butyl (3S)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Relevant articles and documents

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

PYRAZOLO [1, 5 -A] PYRIMIDINES AS ANTIVIRAL AGENTS

The invention provides compounds of Formula I or Formula II: (I), (II) or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective σ1 ligands. Part 2

Herein is described a new class of selective σ1 ligands consisting of tetrahydroisoquinoline-hydantoin (Tic-hydantoin) derivatives. Compound 1a has high affinity (IC50 = 16 nM) for σ1 receptor and is selective in a large panel of therapeutic targets. This study presents structural changes on the side chain of the Tic-hydantoin core. Analogs of higher affinity could be identified (IC50 ≈ 2-3 nM).