252045-82-2Relevant academic research and scientific papers
Cobalt-Catalyzed Alkenylzincation of Unfunctionalized Alkynes
Wu, Junliang,Yoshikai, Naohiko
, p. 336 - 340 (2016)
While transition metal catalyzed addition reactions of arylmetal reagents to unfunctionalized alkynes have been extensively developed in the last decade, analogous reactions using alkenylmetal reagents remain rare regardless of their potential utility for the synthesis of unsymmetrical 1,3-dienes. Reported herein is the development of a cobalt/diphosphine catalyst which promotes efficient and stereoselective addition of alkenylzinc reagents to unfunctionalized internal alkynes. The resulting dienylzinc species serve as versatile intermediates for further synthetic transformations.
Synthesis of isoindolo[2,1-α]indoles by the palladium-catalyzed annulation of internal acetylenes
Roesch,Larock
, p. 412 - 420 (2007/10/03)
A wide variety of substituted isoindolo[2,1-α]indoles have been prepared via annulation of internal alkynes by imines derived from o-iodoanilines in the presence of a palladium catalyst. This methodology provides an extremely efficient route for the synth
