252045-83-3

Upstream product

• 58313-23-8 3-iodobenzoic acid methyl ester 
• 693-02-7 hex-1-yne 
• 542-69-8 1-iodo-butane 
• 178742-95-5 ethyl 3-(ethynyl)benzoate 

Downstream Products

• 1614230-88-4 2-(3-(hex-1-yn-1-yl)phenyl)propan-2-ol 
• 1614230-94-2 ethyl 3-((1E,3E)-hexa-1,3-dien-1-yl)benzoate 
• 1614230-96-4 ethyl 3-((1E,3E)-hexa-1,3-dien-1-yl)benzoate 

Relevant academic research and scientific papers

Synthesis of isoindolo[2,1-α]indoles by the palladium-catalyzed annulation of internal acetylenes

A wide variety of substituted isoindolo[2,1-α]indoles have been prepared via annulation of internal alkynes by imines derived from o-iodoanilines in the presence of a palladium catalyst. This methodology provides an extremely efficient route for the synth

Soft propargylic deprotonation: Designed ligand enables au-catalyzed isomerization of alkynes to 1,3-Dienes

By functionalizing the privileged biphenyl-2-ylphosphine with a basic amino group at the rarely explored 3′ position, the derived gold(I) complex possesses orthogonally positioned "push" and "pull" forces, which enable for the first time soft propargylic deprotonation and permit the bridging of a difference of >26 pKa units (in DMSO) between a propargylic hydrogen and a protonated tertiary aniline. The application of this design led to efficient isomerization of alkynes into versatile 1,3-dienes with synthetically useful scope under mild reaction conditions.