252046-10-9Relevant academic research and scientific papers
An asymmetric synthesis of (+)-grandisol, a constituent of the aggregation pheromone of the cotton boll weevil, via a kinetic resolution
Hamon,Tuck
, p. 7839 - 7846 (2000)
A novel approach to the asymmetric synthesis of (+)-grandisol, (1R,2S)-isopropenyl-1-methylcyclobutaneethanol, involves the use of catalytic kinetic resolution of a primary allylic alcohol, [(1RS,5SR)-5-methylbicyclo[3.2.0]hept-2-en-2-yl] methanol. The allylic alcohol is prepared in four steps from simple achiral materials involving the use of a modified Shapiro reaction. The resolved alcohol (95% ee) is then reduced in two steps to the corresponding methyl alkene, (1S,5R)-2,5-dimethylbicyclo[3.2.0]hept-2-ene. This alkene is converted to (+)-grandisol (95% ee), in three steps, by modified literature procedures.
A new asymmetric synthesis of (+)-grandisol via a kinetic resolution
Hamon, David P.G.,Tuck, Kellie L.
, p. 7569 - 7572 (1999)
A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.).
